Domeier Phillip P, Ziegler Steven F
Center for Fundamental Immunology, Benaroya Research Institute, 1201 9th Avenue, Seattle, WA 98101, United States.
J Leukoc Biol. 2025 Feb 13;117(2). doi: 10.1093/jleuko/qiae216.
Thymic stromal lymphopoietin is an established pleotropic alarmin cytokine that is generated at barrier tissues to induce type 2 immune responses, but its role in regulating the diversity of B cells is poorly understood. Here, we will highlight the key findings that underpin our limited understanding of the role thymic stromal lymphopoietin in modulating different stages of B cell development. We will also provide an overview of how thymic stromal lymphopoietin drives B cell-mediated immune disease and how novel thymic stromal lymphopoietin-blocking biologics could be used to modulate B cell responses. Thymic stromal lymphopoietin is critical for the regulation, diversity, and longevity of humoral immunity.
胸腺基质淋巴细胞生成素是一种公认的多效警报素细胞因子，在屏障组织中产生以诱导2型免疫反应，但其在调节B细胞多样性方面的作用仍知之甚少。在这里，我们将重点介绍一些关键发现，这些发现支撑了我们对胸腺基质淋巴细胞生成素在调节B细胞发育不同阶段作用的有限理解。我们还将概述胸腺基质淋巴细胞生成素如何驱动B细胞介导的免疫疾病，以及新型胸腺基质淋巴细胞生成素阻断生物制剂如何用于调节B细胞反应。胸腺基质淋巴细胞生成素对体液免疫的调节、多样性和持久性至关重要。
