[Effect of ethinyl estradiol sulfonate/norethisterone acetate on PRI secretion in pubertal girls].

In 13 healthy tall girls the influence of the hormonal treatment with depotestrogen ethinylestradiolsulfonate and norethisterone acetate was investigated on the basal and TRH stimulated PRL secretion. The investigations were performed before treatment, during the 8th to 11th cycles of treatment, and in the 4th month after finishing the therapy. PRL levels were determined by RIA. Under treatment significant higher basal PRL levels were found than before (p less than 0.05), but never hyperprolactinemic values. The responsibility of the lactotropic cells to TRH stimulation was increased, too.