Abe K, Matsuura N, Nohara Y, Fujita H, Fujieda K, Kato T, Mikami Y
Tohoku J Exp Med. 1984 Mar;142(3):283-8. doi: 10.1620/tjem.142.283.
Plasma prolactin (PRL) response to synthetic thyrotropin-releasing hormone (TRH) was studied in six patients with pubertal gynecomastia, five patients with premature thelarche and nine female patients with idiopathic precocious puberty. The basal concentration of plasma PRL was higher (p less than 0.01) in pubertal gynecomastia as compared to control, while baseline plasma PRL levels in premature thelarche and idiopathic precocious puberty were similar to those in controls. Plasma PRL level after TRH in patients with pubertal gynecomastia was higher (p less than 0.01) than that in control, while plasma PRL responses to TRH in idiopathic precocious puberty and premature thelarche were comparable to those controls. The TRH-induced PRL release was more enhanced during treatment with cyproterone acetate (CA) than before CA therapy in four of five patients with idiopathic precocious puberty. These data suggest that the enhanced release of PRL may, at least in part, contribute to breast enlargement in pubertal gynecomastia and that seen in idiopathic precocious puberty and premature thelarche may not depend on the PRL secretion. The prolonged administration of CA enhances the PRL responsiveness to TRH.
对6例青春期男性乳腺增生症患者、5例乳房过早发育患者和9例特发性性早熟女性患者，研究了血浆催乳素（PRL）对合成促甲状腺激素释放激素（TRH）的反应。与对照组相比，青春期男性乳腺增生症患者的血浆PRL基础浓度较高（p<0.01），而乳房过早发育和特发性性早熟患者的基线血浆PRL水平与对照组相似。青春期男性乳腺增生症患者TRH刺激后的血浆PRL水平高于对照组（p<0.01），而特发性性早熟和乳房过早发育患者对TRH的血浆PRL反应与对照组相当。在5例特发性性早熟患者中，有4例在醋酸环丙孕酮（CA）治疗期间，TRH诱导的PRL释放比CA治疗前增强。这些数据表明，PRL释放增强可能至少部分导致青春期男性乳腺增生症中的乳腺增大，而特发性性早熟和乳房过早发育中的乳腺增大可能不依赖于PRL分泌。长期给予CA可增强PRL对TRH的反应性。
