Kuhn N, Blunck W, Stahnke N, Wiebel J, Willig R P
Acta Paediatr Scand. 1977 Mar;66(2):161-7. doi: 10.1111/j.1651-2227.1977.tb07828.x.
36 tall girls aged 10.3 to 15.5 years were treated with ethinylestradiol (0.5 mg/day) and norethisterone (15 mg/day). To date treatment for seventeen girls has been completed. Before treatment their bone age ranged from 11.0 to 13.5 years and mean height prediction was 185.19 cm (181.40-193.00 cm). After about two years of treatment their final height averaged 178.96 cm (171.60-183.50 cm). Predicted height was reduced by an average of 6.23 cm. The reduction in final height was significantly greater when therapy was started before a bone age of 12 years. Thirteen girls, re-examined after discontinuation of therapy, all had regular menstrual bleeding within six months. There were no serious or irreversible side effects during the period of observation.
36名年龄在10.3至15.5岁的高个子女孩接受了乙炔雌二醇（0.5毫克/天）和炔诺酮（15毫克/天）的治疗。迄今为止，17名女孩已完成治疗。治疗前，她们的骨龄在11.0至13.5岁之间，平均身高预测为185.19厘米（181.40 - 193.00厘米）。经过约两年的治疗，她们的最终身高平均为178.96厘米（171.60 - 183.50厘米）。预测身高平均降低了6.23厘米。当在骨龄12岁之前开始治疗时，最终身高的降低明显更大。13名女孩在停止治疗后接受复查，均在六个月内出现规律月经出血。在观察期间没有严重或不可逆的副作用。
