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[脑膜炎球菌与人类A组和B组红细胞的抗原亲和力]

[Antigenic affinity of meningococci and human A- and B-group erythrocytes].

作者信息

Deviatkina N P, Demina A A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1985 Dec(12):3-5.

PMID:3937398
Abstract

The use of the modified method of isohemagglutinin adsorption by microbial antigens in experiments with the causative agent of meningococcal infection has led, for the first time, to the detection of meningococcal antigens affined to the antigens of human erythrocytes, groups A and B. The antigenic affinity of group A erythrocytes and meningococci has proved to be more pronounced in meningococcal strains isolated from the spinal fluid of patients than in cultures obtained from the nasopharynx of healthy persons. The detection of the affinity of these antigens makes it possible to explain the mechanism of differences in the susceptibility of persons with different blood groups to meningococcal infection by "antigenic mimicry".

摘要

在脑膜炎球菌感染病原体的实验中,采用微生物抗原吸附同种血细胞凝集素的改良方法,首次检测到与人类红细胞A组和B组抗原相关的脑膜炎球菌抗原。已证明,从患者脑脊液中分离出的脑膜炎球菌菌株中,A组红细胞与脑膜炎球菌的抗原亲和力比从健康人鼻咽部获得的培养物中更为明显。这些抗原亲和力的检测使得通过“抗原模拟”来解释不同血型的人对脑膜炎球菌感染易感性差异的机制成为可能。

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