促性腺激素释放激素类似物（布舍瑞林）治疗中枢性性早熟女童的长期疗效
Long-term results of GnRH analogue (Buserelin) treatment in girls with central precocious puberty.
作者信息
Brauner R, Thibaud E, Bischof P, Sizonenko P C, Rappaport R
出版信息
Acta Paediatr Scand. 1985 Nov;74(6):945-9. doi: 10.1111/j.1651-2227.1985.tb10062.x.
Abstract
The GnRH analogue Buserelin was given for one year to six girls with central precocious puberty in a daily subcutaneous dose of 20 micrograms/kg/day. A decrease of plasma estradiol and vaginal maturation index to prepubertal values was obtained in 5 out of 6 cases. Bone maturation decreased and final predicted adult height improved significantly. This analogue of GnRH appears to be an effective medication for gonadotropin dependent precocious puberty in girls.
摘要
将促性腺激素释放激素类似物布舍瑞林以每日皮下注射剂量20微克/千克/天给予6名中枢性性早熟女童，为期一年。6例中有5例血浆雌二醇水平及阴道成熟指数降至青春期前水平。骨成熟减缓，最终预测成年身高显著提高。这种促性腺激素释放激素类似物似乎是治疗女童促性腺激素依赖性性早熟的有效药物。
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