促性腺激素释放激素类似物治疗性早熟时对促性腺激素释放激素（GnRH）的反应
Gonadotrophin responses to GnRH in precocious puberty treated with GnRH analogue.
作者信息
Donaldson M D, Stanhope R, Lee T J, Price D A, Brook C G, Savage D C
出版信息
Clin Endocrinol (Oxf). 1984 Nov;21(5):499-503. doi: 10.1111/j.1365-2265.1984.tb01387.x.
Abstract
The gonadotrophin releasing hormone analogue Buserelin was given by intranasal spray to 13 children with precocious puberty. The LH responses to GnRH reverted to prepubertal levels in the boys on 200-400 micrograms daily of the analogue while doses of 400-1200 micrograms daily were needed to suppress the girls. The significance of this apparent sex difference is uncertain.
摘要
向13名性早熟儿童经鼻喷雾给予促性腺激素释放激素类似物布舍瑞林。对于男孩，每日给予200 - 400微克该类似物时，促黄体生成素（LH）对促性腺激素释放激素（GnRH）的反应恢复到青春期前水平；而女孩则需要每日400 - 1200微克的剂量才能得到抑制。这种明显的性别差异的意义尚不确定。
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