Rathnam Jeyamalar T Thurai, Grigg Matthew J, Dondorp Arjen M, William Timothy, Rajasekhar Megha, Rajahram Giri, Simpson Julie A, Barber Bridget E, Anstey Nicholas M
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia.
J Infect Dis. 2025 Mar 17;231(3):e566-e569. doi: 10.1093/infdis/jiae490.
Reduced deformability of both infected and uninfected red blood cells (RBCs) contributes to pathogenesis in Plasmodium falciparum malaria. Whole-blood RBC deformability (RBC-D) is not well characterized in Plasmodium vivax malaria. We used a laser-assisted optical rotational cell analyzer to measure the RBC-D in fresh whole-blood samples from Malaysian patients with vivax malaria (n = 25). Deformability of whole-blood RBCs, the vast majority of which were uninfected, was reduced in vivax malaria compared with controls (n = 15), though not to the same degree as in falciparum malaria (n = 90). Reduced RBC-D may contribute to the pathogenesis of vivax malaria, including splenic retention of uninfected RBCs.
感染和未感染的红细胞（RBCs）的变形性降低均促成了恶性疟原虫疟疾的发病机制。间日疟原虫疟疾中全血红细胞变形性（RBC-D）的特征尚不明确。我们使用激光辅助光学旋转细胞分析仪来测量马来西亚间日疟患者新鲜全血样本（n = 25）中的RBC-D。与对照组（n = 15）相比，间日疟原虫疟疾患者全血RBCs（其中绝大多数未被感染）的变形性降低，尽管程度不如恶性疟原虫疟疾患者（n = 90）。RBC-D降低可能促成间日疟原虫疟疾的发病机制，包括未感染RBCs在脾脏中的滞留。
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