乙醇对雄性大鼠中枢单胺合成的年龄依赖性影响。

Age-dependent effects of ethanol on central monoamine synthesis in the male rat.

作者信息

Engel J A, Rydberg U

出版信息

Acta Pharmacol Toxicol (Copenh). 1985 Nov;57(5):336-9. doi: 10.1111/j.1600-0773.1985.tb00054.x.

DOI:10.1111/j.1600-0773.1985.tb00054.x

Abstract

In the present study, the effect of ethanol on central monoamine synthesis in developing and adult male rats was studied by measuring the accumulation of DOPA and 5-hydroxytryptophan after inhibition of aromatic amino acid decarboxylase. Before adolescence, ethanol caused a decrease of DOPA accumulation in the whole rat brain, while after adolescence ethanol increased the DOPA synthesis. Ethanol had no effect on the serotonin synthesis at any of the ages studied. It is suggested that hormonal events occurring during puberty may be of importance for the stimulatory properties of ethanol observed at adult age.

摘要

在本研究中，通过测量芳香族氨基酸脱羧酶被抑制后多巴（DOPA）和5-羟色氨酸的积累，研究了乙醇对发育中和成年雄性大鼠中枢单胺合成的影响。青春期前，乙醇导致全脑多巴积累减少，而青春期后乙醇增加了多巴合成。在所研究的任何年龄段，乙醇对血清素合成均无影响。提示青春期发生的激素变化可能对成年期观察到的乙醇刺激特性具有重要意义。