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[Effect of triiodothyronine and methylthiouracil on the enzymatic activity of biogenic amine metabolism in rat brain synaptosomes].

作者信息

Savitskiĭ S Iu, Kononenko V Ia

出版信息

Farmakol Toksikol. 1978 Jan-Feb;41(1):60-3.

PMID:304815
Abstract

Triiodothyronine injections are shown to lower DOPA decarboxylation and 5-hydroxytryptophan decarboxylation activity and also to decrease the intensity of serotonin and norepinephrine oxidative deamination in the rats' brain synaptosomes. Hypothyroidism produced by 6-methylthiouracil administration was accompanied by intensification of the DOPA-decarboxylase activity and monamine oxidase transformation into serotonin and norepinephrine with no parallel occurring essential changes in the 5-hydroxytryptophan decarboxylation.

摘要

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