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川崎病冠状动脉血管炎致儿童霍奇金淋巴瘤心源性猝死 1 例并文献复习

Sudden cardiac death caused by Kawasaki coronary artery vasculitis in a child with Hodgkin's lymphoma. Case report and literature review.

机构信息

Department of Precision and Regenerative Medicine and Jonian Area, Pathology Unit, University of Bari, Bari, Italy; Department of Experimental Medicine, PhD Course in Public Health, University of Campania "Luigi Vanvitelli", Naples, Italy.

Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova - Azienda Ospedaliera, Padova, Italy.

出版信息

Cardiovasc Pathol. 2025 Jan-Feb;74:107700. doi: 10.1016/j.carpath.2024.107700. Epub 2024 Oct 5.

Abstract

Coronary artery vasculitis is a rare pathological condition and is often a manifestation of systemic vasculitis, such as Polyarteritis Nodosa, Kawasaki Disease, Takayasu Arteritis, and Giant Cell Arteritis, with Kawasaki Disease being the most common cause in children. We present the autopsy case of a 6-year-old boy with classic Hodgkin lymphoma who died of sudden cardiac death due to thrombosis caused by vasculitis, which exclusively affected the coronary arteries and was suggestive of Kawasaki Disease. To further investigate the histological features of Kawasaki Disease across all age groups, we conducted a literature review using the search terms "Kawasaki AND vasculitis AND histopathology" and "Kawasaki vasculitis histopathology" in Scopus, Google Scholar, and PubMed, covering the period from 1967 to 2023. The inclusion criteria were as follows: coronary histology (inflammation and/or aneurysm and/or thrombosis), postmortem studies, English language, free articles, all age groups, case reports, and case series.

摘要

冠状动脉血管炎是一种罕见的病理状况,通常是全身血管炎的表现,如结节性多动脉炎、川崎病、大动脉炎和巨细胞动脉炎,其中川崎病在儿童中最为常见。我们报告了一例 6 岁男孩的尸检病例,该男孩患有经典霍奇金淋巴瘤,由于血管炎引起的血栓形成导致心源性猝死,该血管炎仅累及冠状动脉,提示川崎病。为了进一步研究所有年龄段川崎病的组织学特征,我们使用 Scopus、Google Scholar 和 PubMed 中的搜索词“Kawasaki AND vasculitis AND histopathology”和“Kawasaki vasculitis histopathology”进行了文献回顾,涵盖了 1967 年至 2023 年的时间段。纳入标准为:冠状动脉组织学(炎症和/或动脉瘤和/或血栓形成)、尸检研究、英语、免费文章、所有年龄段、病例报告和病例系列。

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