Absmeier Eva, Heyd Florian
Laboratory of mRNA translation and turnover, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Laboratory of RNA Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
J Biol Chem. 2024 Nov;300(11):107865. doi: 10.1016/j.jbc.2024.107865. Epub 2024 Oct 5.
Temperature is an omnipresent factor impacting on many aspects of life. In bacteria and ectothermic eukaryotes, various thermosensors and temperature-controlled switches have been described, ranging from RNA thermometers controlling the heat shock response in prokaryotes to temperature-dependent sex determination in reptiles, likely controlled through protein phosphorylation. However, the impact of subtle changes of human core body temperature are only beginning to be acknowledged. In this review, we will discuss thermosensing mechanisms and their functional implications with a focus on mammalian cells, also in the context of disease conditions. We will point out open questions and possible future directions for this emerging research field, which, in addition to molecular-mechanistic insights, holds the potential for the development of new therapeutic approaches.
温度是一个无处不在的因素，影响着生活的许多方面。在细菌和变温真核生物中，已经描述了各种温度传感器和温度控制开关，从控制原核生物热休克反应的RNA温度计到爬行动物中可能通过蛋白质磷酸化控制的温度依赖性性别决定。然而，人体核心体温细微变化的影响才刚刚开始得到认可。在这篇综述中，我们将讨论温度传感机制及其功能意义，重点是哺乳动物细胞，也会涉及疾病状况。我们将指出这个新兴研究领域的开放性问题和可能的未来方向，该领域除了分子机制方面的见解外，还具有开发新治疗方法的潜力。
