Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China.
Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
J Pain. 2024 Dec;25(12):104692. doi: 10.1016/j.jpain.2024.104692. Epub 2024 Oct 5.
The count of locations with chronic pain is widely used in research and clinical practice. However, this approach might be too simplistic to fully capture the complexity of chronic pain experiences. This study identified prevalent patterns of chronic pain locations and evaluated their associations with incident dementia among middle-aged and older adults in the UK. Data were from 445,530 participants who were free of dementia at baseline (2006-2010) in the UK Biobank. We calculated the incidence rates of all-cause dementia by the 20 most prevalent combinations of pain locations assessed at baseline. Cox models were utilized to examine the hazard ratio of incident dementia among each of these 20 combinations compared to 3 groups: 1) participants without chronic pain, 2) participants with only a single chronic pain location not included in the combination, and 3) participants with only a single chronic pain location included in the combination. The 3 most prevalent combinations were neck and back (5.7%), back and knee (5.4%), and neck and knee (4.5%). Chronic back, neck, and knee pain was commonly present either individually or simultaneously in combinations associated with higher dementia rates than persons without chronic pain. The combinations involving back, neck, and knee were associated with higher dementia rates than groups with 1 pain location not included in the combination. Chronic pain is not randomly present in body locations. Understanding how different patterns of chronic pain locations relate to dementia provides new insights into dementia prevention through pain relief. PERSPECTIVE: This article unveils chronic pain patterns and dementia risks in the UK Biobank. Chronic pain in back, neck, and knee presents frequently, either individually or in combinations associated with increased dementia rates. Chronic pain combos correlate with diverse dementia rates, guiding targeted prevention strategies through pain management.
慢性疼痛部位的计数在研究和临床实践中被广泛应用。然而，这种方法可能过于简单化，无法完全捕捉慢性疼痛体验的复杂性。本研究旨在确定慢性疼痛部位的常见模式，并评估其与英国中年和老年人新发痴呆的关系。研究数据来自 UK Biobank 的 445530 名基线时（2006-2010 年）无痴呆的参与者。我们根据基线时评估的 20 种最常见疼痛部位组合，计算了所有原因痴呆的发生率。Cox 模型用于检查这 20 种组合中每种组合与 3 组相比发生痴呆的风险比：1）无慢性疼痛的参与者；2）未包括在组合中的单一慢性疼痛部位的参与者；3）仅包括在组合中的单一慢性疼痛部位的参与者。最常见的三种组合是颈部和背部（5.7%）、背部和膝盖（5.4%）以及颈部和膝盖（4.5%）。慢性背部、颈部和膝盖疼痛通常单独存在或同时存在于与较高痴呆率相关的组合中，而不是没有慢性疼痛的人。涉及背部、颈部和膝盖的组合与不包括在组合中的 1 个疼痛部位的组相比，与较高的痴呆率相关。慢性疼痛并非随机存在于身体部位。了解不同模式的慢性疼痛部位与痴呆的关系，为通过缓解疼痛预防痴呆提供了新的见解。观点：本文揭示了英国生物库中慢性疼痛模式与痴呆风险之间的关系。背部、颈部和膝盖的慢性疼痛经常出现，无论是单独出现还是与增加痴呆风险的组合出现。慢性疼痛组合与不同的痴呆率相关，通过疼痛管理指导有针对性的预防策略。
