Department of Neurosurgery, Affiliated Hospital of Shaoxing University, Shaoxing, China.
Department of Anesthesia and Surgery, Affiliated Hospital of Shaoxing University, Shaoxing, China.
Behav Brain Res. 2025 Jan 5;476:115281. doi: 10.1016/j.bbr.2024.115281. Epub 2024 Oct 5.
Anxiety disorders are multifaceted conditions that engage numerous brain regions and circuits. While the hindbrain is pivotal in fundamental biological functions, its role in modulating emotions has been underappreciated. This review will uncover critical targets and circuits within the hindbrain that are essential for both anxiety and anxiolytic effects, expanding on research obtained through behavioral tests. The bidirectional neural pathways between the hindbrain and other brain regions, with a spotlight on vagal afferent signaling, provide a crucial framework for unraveling the neural mechanisms underlying anxiety. Exploring neural circuits within the hindbrain can help to unravel the neurobiological mechanisms of anxiety and elucidate differences in the expression of these circuits between genders, thereby providing valuable insights for the development of future anxiolytic drugs.
焦虑症是一种多方面的疾病，涉及许多大脑区域和回路。虽然后脑在基本的生物功能中起着关键作用，但它在调节情绪方面的作用一直被低估。本综述将揭示后脑中对焦虑和抗焦虑作用至关重要的关键靶点和回路，这些作用是通过行为测试获得的研究的扩展。后脑与其他大脑区域之间的双向神经通路，特别是迷走神经传入信号，为解开焦虑的神经机制提供了一个重要框架。探索后脑内的神经回路可以帮助揭示焦虑的神经生物学机制，并阐明这些回路在性别之间的表达差异，从而为未来抗焦虑药物的开发提供有价值的见解。
