Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA.
Curr Opin Neurobiol. 2010 Feb;20(1):116-25. doi: 10.1016/j.conb.2010.01.002. Epub 2010 Feb 6.
Neural networks in the hindbrain and spinal cord generate the simple patterns of motor activity that are necessary for breathing and locomotion. These networks function autonomously, producing simple yet flexible rhythmic motor behaviours that are highly responsive to sensory inputs and central control. This review outlines recent advances in our understanding of the genetic programmes controlling the assembly and functioning of circuits in the hindbrain and spinal cord that are responsible for respiration and locomotion. In addition, we highlight the influence that target-derived retrograde signaling and experience-dependent mechanisms have on establishing connectivity, particularly with respect to sensory afferent innervation of the spinal cord.
后脑和脊髓中的神经网络产生了呼吸和运动所必需的简单运动模式。这些网络自主运作，产生简单而灵活的节律性运动行为，对感觉输入和中枢控制高度敏感。这篇综述概述了我们对控制后脑和脊髓中负责呼吸和运动的电路组装和功能的遗传程序的理解的最新进展。此外，我们强调了靶源性逆行信号和经验依赖性机制对建立连接性的影响，特别是在脊髓的感觉传入神经支配方面。
