从电路到行为：脊椎动物的运动网络。
From circuits to behaviour: motor networks in vertebrates.
机构信息
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA.
出版信息
Curr Opin Neurobiol. 2010 Feb;20(1):116-25. doi: 10.1016/j.conb.2010.01.002. Epub 2010 Feb 6.
Abstract
Neural networks in the hindbrain and spinal cord generate the simple patterns of motor activity that are necessary for breathing and locomotion. These networks function autonomously, producing simple yet flexible rhythmic motor behaviours that are highly responsive to sensory inputs and central control. This review outlines recent advances in our understanding of the genetic programmes controlling the assembly and functioning of circuits in the hindbrain and spinal cord that are responsible for respiration and locomotion. In addition, we highlight the influence that target-derived retrograde signaling and experience-dependent mechanisms have on establishing connectivity, particularly with respect to sensory afferent innervation of the spinal cord.
摘要
后脑和脊髓中的神经网络产生了呼吸和运动所必需的简单运动模式。这些网络自主运作，产生简单而灵活的节律性运动行为，对感觉输入和中枢控制高度敏感。这篇综述概述了我们对控制后脑和脊髓中负责呼吸和运动的电路组装和功能的遗传程序的理解的最新进展。此外，我们强调了靶源性逆行信号和经验依赖性机制对建立连接性的影响，特别是在脊髓的感觉传入神经支配方面。
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本文引用的文献
1
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J Neurosci. 2009 Nov 25;29(47):14836-46. doi: 10.1523/JNEUROSCI.2623-09.2009.
2
Math1 is essential for the development of hindbrain neurons critical for perinatal breathing.Math1对于围产期呼吸至关重要的后脑神经元的发育必不可少。
Neuron. 2009 Nov 12;64(3):341-54. doi: 10.1016/j.neuron.2009.10.023.
3
Spinal interneurons differentiate sequentially from those driving the fastest swimming movements in larval zebrafish to those driving the slowest ones.脊髓中间神经元在幼体斑马鱼中依次从驱动最快游泳运动的神经元分化为驱动最慢游泳运动的神经元。
J Neurosci. 2009 Oct 28;29(43):13566-77. doi: 10.1523/JNEUROSCI.3277-09.2009.
4
Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit.γ-氨基丁酸能突触前抑制性回路构建中的严格特异性
Cell. 2009 Oct 2;139(1):161-74. doi: 10.1016/j.cell.2009.08.027.
5
Optogenetic dissection of a behavioural module in the vertebrate spinal cord.脊椎动物脊髓中一个行为模块的光遗传学剖析
Nature. 2009 Sep 17;461(7262):407-10. doi: 10.1038/nature08323.
6
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