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二维配位雷奈酸锶-锰纳米带作为癌症放化疗和免疫治疗的佐剂。

Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy.

机构信息

State Key Laboratory for Organic Electronics and Information Displays (SKLOEID), School of Chemistry and Life Sciences, Nanjing University of Posts and Telecommunications, Nanjing, China.

Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, College of Optical Engineering & Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, Nanjing, China.

出版信息

Nat Commun. 2024 Oct 8;15(1):8692. doi: 10.1038/s41467-024-53084-w.

DOI:10.1038/s41467-024-53084-w
PMID:39375342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11458765/
Abstract

The irradiated tumor itself represents an opportunity to establish endogenous in situ vaccines. However, such in situ cancer vaccination (ISCV) triggered by radiation therapy (RT) alone is very weak and hardly elicits systemic anticancer immunity. In this study, we develop two-dimensional risedronate-manganese nanobelts (RMn-NBs) as an adjuvant for RT to address this issue. RMn-NBs exhibit good T magnetic resonance imaging performance and enhanced Fenton-like catalytic activity, which induces immunogenic cell death. RMn-NBs can inhibit the HIF-1α/VEGF axis to empower RT and synchronously activate the cGAS/STING pathway for promoting the secretion of type I interferon, thereby boosting RT-triggered ISCV and immune checkpoint blockade therapy against primary and metastatic tumors. RMn-NBs as a nano-adjuvant for RT show good biocompatibility and therapeutic efficacy, presenting a promising prospect for cancer radiotherapy and immunotherapy.

摘要

受辐照的肿瘤本身代表了建立内源性原位疫苗的机会。然而，仅通过放射治疗（RT）引发的这种原位癌症疫苗接种（ISCV）非常弱，几乎无法引发全身性抗癌免疫。在这项研究中，我们开发了二维利塞膦酸盐-锰纳米带（RMn-NBs）作为 RT 的佐剂来解决这个问题。RMn-NBs 表现出良好的 T 磁共振成像性能和增强的类芬顿催化活性，诱导免疫原性细胞死亡。RMn-NBs 可以抑制 HIF-1α/VEGF 轴来增强 RT，并同步激活 cGAS/STING 通路以促进 I 型干扰素的分泌，从而增强 RT 触发的 ISCV 和免疫检查点阻断治疗原发性和转移性肿瘤。作为 RT 的纳米佐剂，RMn-NBs 具有良好的生物相容性和治疗效果，为癌症放射治疗和免疫治疗带来了广阔的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/7dd92aa18047/41467_2024_53084_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/fc6932299717/41467_2024_53084_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/a482c2277fe4/41467_2024_53084_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/5629184c7c78/41467_2024_53084_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/a0e4c99c2269/41467_2024_53084_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/7e7dd69e892a/41467_2024_53084_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/dd046eaa6408/41467_2024_53084_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/4bf66e77c538/41467_2024_53084_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/fc466ae3a90a/41467_2024_53084_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/7dd92aa18047/41467_2024_53084_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/fc6932299717/41467_2024_53084_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/a482c2277fe4/41467_2024_53084_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/5629184c7c78/41467_2024_53084_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/a0e4c99c2269/41467_2024_53084_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/7e7dd69e892a/41467_2024_53084_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/dd046eaa6408/41467_2024_53084_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/4bf66e77c538/41467_2024_53084_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/fc466ae3a90a/41467_2024_53084_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/11458765/7dd92aa18047/41467_2024_53084_Fig9_HTML.jpg

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引用本文的文献

[1]
Bioinspired ruthenium-manganese-oxygen complex for biocatalytic and radiosensitization therapies to eradicate primary and metastatic tumors.

Nat Commun. 2025-8-16

[2]
Unlocking the therapeutic potential of the STING signaling pathway in anti-tumor treatment.

Clin Exp Med. 2025-8-12

[3]
Advanced nanotheranostic approaches for targeted glioblastoma treatment: a synergistic fusion of CRISPR-Cas gene editing, AI-driven tumor profiling, and BBB-modulation.

Med Oncol. 2025-8-7

[4]
Enhancing radiotherapy-induced anti-tumor immunity via nanoparticle-mediated STING agonist synergy.

Mol Cancer. 2025-6-11

[5]
Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy.

Biomater Res. 2025-2-28

[6]
Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade.

J Nanobiotechnology. 2025-2-7

本文引用的文献

[1]
Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination.

Nat Commun. 2024-5-9

[2]
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Nat Rev Clin Oncol. 2023-8

[3]
The cGAS-STING pathway and cancer.

Nat Cancer. 2022-12

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J Am Chem Soc. 2022-12-7

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Chem Sci. 2022-11-2

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Sci Transl Med. 2022-11-9

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Nat Cancer. 2022-8

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Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade.

Nat Commun. 2022-8-23

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