Department of Obstetrics and Gynecology, Republic of Türkiye Ministry of Health Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye.
, Present address: Basaksehir Neighborhood, G-434 Street, No: 2L, Basaksehir, Istanbul, Türkiye.
Sci Rep. 2024 Oct 7;14(1):23351. doi: 10.1038/s41598-024-73653-9.
Preeclampsia (PE) occurs due to inadequate spiral artery/trophoblast remodeling in early pregnancy. Endometases are involved in the remodeling of spiral arteries and placental trophoblasts. This study aimed to investigate differences in blood endometase levels between pregnant women with hypertensive disorders (PE and gestational hypertension [GHT]) and healthy pregnant women and to evaluate whether plasma endometase values could play a predictive role in PE or GHT diagnosis. A total of 90 pregnant women (n(PE) = 30, n(GHT) = 30, n(healthy pregnant) = 30) who presented at the hospital between December 2023 and May 2024 and were 26-32 years of age and > 20 weeks pregnant were included in the study. The endometase levels in all pregnant women were determined in maternal blood plasma via enzyme-linked immunosorbent assay. The endometase values were recalculated according to albumin values, and corrected endometase (cEndo) values were determined. No significant differences in blood endometase levels were observed between the groups (p > 0.05). The cEndo value was significantly lower in the PE and GHT groups than in the control group (p < 0.05). There was no statistically significant difference in the cEndo values between the PE and GHT groups (p > 0.05). A statistically significant negative linear relationship was detected between cEndo values and mean systolic blood pressure and mean diastolic blood pressure (p < 0.05). The cEndo values in the PE and GHT groups at early (≤ 32 weeks 3 days) and late pregnancy were compared, and no statistically significant difference was detected (p > 0.05). Maternal blood cEndo values may play a successful role in distinguishing hypertensive diseases of pregnancy (PE + GHT) from healthy pregnant women. cEndo does not play an effective role in the differential diagnosis between pregnant women with PE and those with GHT. Studies with larger patient populations are needed.
子痫前期（PE）是由于早孕时螺旋动脉/滋养层改建不足引起的。溶酶体在螺旋动脉和胎盘滋养层改建中起作用。本研究旨在探讨高血压疾病（PE 和妊娠期高血压[GHT]）孕妇与健康孕妇之间血液溶酶体水平的差异，并评估血浆溶酶体值是否在 PE 或 GHT 诊断中起预测作用。
2023 年 12 月至 2024 年 5 月期间，共纳入 90 名年龄 26-32 岁、孕周>20 周的医院就诊的孕妇（n(PE)=30、n(GHT)=30、n(健康孕妇)=30）。采用酶联免疫吸附法测定所有孕妇的母血血浆溶酶体水平。根据白蛋白值重新计算溶酶体值，并确定校正溶酶体（cEndo）值。各组间血液溶酶体水平无显著差异（p>0.05）。PE 和 GHT 组的 cEndo 值明显低于对照组（p<0.05）。PE 和 GHT 组间 cEndo 值无统计学差异（p>0.05）。cEndo 值与平均收缩压和平均舒张压呈显著负线性关系（p<0.05）。比较 PE 和 GHT 组早孕期（≤32 周 3 天）和晚孕期的 cEndo 值，无统计学差异（p>0.05）。
母体血 cEndo 值可能在鉴别妊娠高血压疾病（PE+GHT）与健康孕妇方面发挥作用。cEndo 不能有效鉴别 PE 和 GHT 孕妇。需要更大的患者人群研究。
