Gao Yamei, Huo Shaohu, Chen Chao, Du Shiyu, Xia Ruiyuan, Liu Jian, Chen Dandan, Diao Ziyue, Han Xin, Yin Zhiqiang
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
J Biomed Res. 2024 Oct 8;39(1):1-17. doi: 10.7555/JBR.38.20240119.
Rod-shaped gold nanomaterials, known as gold nanorods (GNRs), may undergo specific surface modification, because of their straightforward surface chemistry. This feature makes them appropriate for use as functional and biocompatible nano-formulations. By optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region, which corresponds to the near-infrared bio-tissue window, GNRs with appropriate modifications may improve the results of photothermal treatment (PTT). In dermatology, potential noninvasive uses of GNRs to enhance wound healing, manage infections, combat cutaneous malignancies, and remodel skin tissues PTT have attracted research attention in recent years. The review discussed the basic properties of GNRs, such as their shape, size, optical performance, photothermal efficiency, and metabolism. Then, the disadvantages of using these particles in photodynamic therapy are highlighted. Next, biological applications of GNRs-based PTT are explored in detail. Finally, the limitations and future perspectives of this research are addressed, providing a comprehensive perspective on the potential GNRs with PTT.
棒状金纳米材料，即金纳米棒（GNRs），因其表面化学性质简单，可进行特定的表面修饰。这一特性使其适合用作功能性和生物相容性纳米制剂。通过优化纵向局域表面等离子体共振在近红外区域的吸收，该区域对应于近红外生物组织窗口，经过适当修饰的金纳米棒可以改善光热治疗（PTT）的效果。在皮肤科领域，金纳米棒在促进伤口愈合、控制感染、对抗皮肤恶性肿瘤以及重塑皮肤组织等光热治疗方面的潜在非侵入性应用近年来引起了研究关注。该综述讨论了金纳米棒的基本性质，如形状、尺寸、光学性能、光热效率和代谢。然后，强调了在光动力疗法中使用这些粒子的缺点。接下来，详细探讨了基于金纳米棒的光热治疗的生物学应用。最后，阐述了该研究的局限性和未来展望，为金纳米棒在光热治疗方面的潜在应用提供了全面的视角。
