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撤回声明:PNU-74654增强5-氟尿嘧啶对乳腺癌的抗增殖作用,并通过Wnt途径拮抗凝血酶诱导的细胞生长。

RETRACTION: PNU-74654 enhances the antiproliferative effects of 5-FU in breast cancer and antagonizes thrombin-induced cell growth via the Wnt pathway.

出版信息

J Cell Physiol. 2024 Dec;239(12):e31462. doi: 10.1002/jcp.31462. Epub 2024 Oct 7.

Abstract

F. Rahmani, F. Amerizadeh, S. M. Hassanian, M. Hashemzehi, S.-N. Nasiri, H. Fiuji, G. A. Ferns, M. Khazaei, and A. Avan, "PNU-74654 Enhances the Antiproliferative Effects of 5-FU in Breast Cancer and Antagonizes Thrombin-induced Cell Growth via the Wnt Pathway," Journal of Cellular Physiology 234, no. 8 (2019): 14123-14132, https://doi.org/10.1002/jcp.28104. The above article, published online on 11 January 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Robert Heath; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by a third party on the data presented in the article. Specifically, image elements in Figure 1c were previously published by the same author group in a different scientific context. Additionally, the panels representing the histological staining corresponding to the "Control" and "5-FU" groups in Figure 3b were found to originate from the same biological sample. Finally, splicing sites have been detected within Figure 6b. The concerns were not satisfactorily addressed by the authors upon request. Accordingly, retraction is warranted as the editors have lost trust in the data presented in the article and in its conclusions. The corresponding author Majid Khazaei disagrees with the decision of retraction. No confirmation was obtained by the remaining co-authors.

摘要

F. 拉赫马尼、F. 阿梅里扎德、S. M. 哈桑尼亚尼、M. 哈谢姆泽希、S.-N. 纳西里、H. 富士、G. A. 费恩斯、M. 哈扎伊和A. 阿万,“PNU - 74654增强5 - 氟尿嘧啶对乳腺癌的抗增殖作用并通过Wnt途径拮抗凝血酶诱导的细胞生长”,《细胞生理学杂志》234卷,第8期(2019年):14123 - 14132页,https://doi.org/10.1002/jcp.28104 。上述文章于2019年1月11日在线发表于威利在线图书馆(wileyonlinelibrary.com),经期刊主编罗伯特·希思与威利期刊有限责任公司协商后被撤回。撤回是因为第三方对文章中呈现的数据提出了担忧。具体而言,图1c中的图像元素先前由同一作者团队在不同的科学背景下发表过。此外,发现图3b中代表“对照”和“5 - 氟尿嘧啶”组的组织学染色图来自同一生物样本。最后,在图6b中检测到了拼接位点。作者应要求未能令人满意地解决这些担忧。因此,由于编辑对文章中呈现的数据及其结论失去了信任,撤回是必要的。通讯作者马吉德·哈扎伊不同意撤回的决定。其余共同作者未确认此事。

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