纳米颗粒向肿瘤的递送：从增强渗透与滞留效应和主动靶向机制到临床影响
Nanoparticle Delivery to Tumours: From EPR and ATR Mechanisms to Clinical Impact.
作者信息
Dasgupta Anshuman, Sofias Alexandros Marios, Kiessling Fabian, Lammers Twan
机构信息
Institute for Experimental Molecular Imaging, Center for Biohybrid Medical Systems, RWTH Aachen University Clinic, Aachen, Germany.
出版信息
Nat Rev Bioeng. 2024 Jun 4;2(9):714-716. doi: 10.1038/s44222-024-00203-3.
Abstract
New insights into active versus passive nanoparticle tumour entry and exit mechanisms are enriching the understanding of tumour-targeted drug delivery. Here, we align the principles of the enhanced permeability and retention (EPR) and active transport and retention (ATR), and outline how their mechanistic features may be employed to improve the performance and clinical impact of cancer nanomedicines.
摘要
关于纳米颗粒主动与被动进入和离开肿瘤机制的新见解正在丰富对肿瘤靶向药物递送的理解。在此，我们将增强渗透与滞留（EPR）和主动转运与滞留（ATR）的原理相结合，并概述如何利用它们的机制特征来提高癌症纳米药物的性能和临床影响。
相似文献
1
Nanoparticle Delivery to Tumours: From EPR and ATR Mechanisms to Clinical Impact.纳米颗粒向肿瘤的递送：从增强渗透与滞留效应和主动靶向机制到临床影响
Nat Rev Bioeng. 2024 Jun 4;2(9):714-716. doi: 10.1038/s44222-024-00203-3.
2
The exit of nanoparticles from solid tumours.纳米颗粒从实体瘤中的排出。
Nat Mater. 2023 Oct;22(10):1261-1272. doi: 10.1038/s41563-023-01630-0. Epub 2023 Aug 17.
3
Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect.通过增强的通透性和保留（EPR）效应递送至高分子纳米星进行分子成像和内放射治疗。
Theranostics. 2020 Jan 1;10(2):567-584. doi: 10.7150/thno.36777. eCollection 2020.
4
Reappraisal of anticancer nanomedicine design criteria in three types of preclinical cancer models for better clinical translation.重新评估三种临床前癌症模型中的抗癌纳米医学设计标准，以更好地进行临床转化。
Biomaterials. 2021 Aug;275:120910. doi: 10.1016/j.biomaterials.2021.120910. Epub 2021 Jun 3.
5
Approaches to Improve Macromolecule and Nanoparticle Accumulation in the Tumor Microenvironment by the Enhanced Permeability and Retention Effect.通过增强渗透与滞留效应改善肿瘤微环境中大分子和纳米颗粒蓄积的方法
Polymers (Basel). 2022 Jun 27;14(13):2601. doi: 10.3390/polym14132601.
6
Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms.利用 EPR 效应和其他靶向机制增强药物递送至实体瘤的策略。
Adv Drug Deliv Rev. 2022 Sep;188:114449. doi: 10.1016/j.addr.2022.114449. Epub 2022 Jul 11.
7
What Went Wrong with Anticancer Nanomedicine Design and How to Make It Right.抗癌纳米药物设计出了什么问题以及如何纠正
ACS Nano. 2020 Oct 27;14(10):12281-12290. doi: 10.1021/acsnano.9b09713. Epub 2020 Oct 6.
8
Enhanced permeability and retention effect-focused tumor-targeted nanomedicines: latest trends, obstacles and future perspective.聚焦增强渗透与滞留效应的肿瘤靶向纳米药物：最新趋势、障碍与未来展望
Nanomedicine (Lond). 2022 Aug;17(18):1213-1216. doi: 10.2217/nnm-2022-0065. Epub 2022 Sep 22.
9
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation.提高 EPR 效应的策略：一种机制观点和临床转化。
J Control Release. 2022 May;345:512-536. doi: 10.1016/j.jconrel.2022.03.043. Epub 2022 Mar 23.
10
Macrophages as an active tumour-targeting carrier of SN38-nanoparticles for cancer therapy.巨噬细胞作为一种主动靶向肿瘤的 SN38 纳米颗粒载体用于癌症治疗。
J Drug Target. 2018 Jun-Jul;26(5-6):458-465. doi: 10.1080/1061186X.2017.1419359. Epub 2017 Dec 27.
引用本文的文献
1
Nanoparticle-Based Delivery Strategies for Combating Drug Resistance in Cancer Therapeutics.基于纳米颗粒的癌症治疗中抗耐药性递送策略
Cancers (Basel). 2025 Aug 11;17(16):2628. doi: 10.3390/cancers17162628.
2
Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors.突破肿瘤屏障：膜联蛋白A2介导的转胞吞作用增强胰腺和乳腺肿瘤中的药物递送
Nat Commun. 2025 Jul 15;16(1):6531. doi: 10.1038/s41467-025-61434-5.
3
Advances in nanoparticle-based doxorubicin delivery: precision strategies for targeted treatment of triple-negative breast cancer.基于纳米颗粒的阿霉素递送研究进展：三阴性乳腺癌靶向治疗的精准策略
Discov Nano. 2025 Jul 14;20(1):111. doi: 10.1186/s11671-025-04308-5.
4
Sonoafterglow nanoprobes for deep-tissue imaging of peroxynitrite.用于过氧亚硝酸盐深层组织成像的声致余辉纳米探针。
Nat Protoc. 2025 Jun 26. doi: 10.1038/s41596-025-01202-3.
5
Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer.癌症光疗法与免疫疗法的临床结果及财务方面的比较分析
Adv Sci (Weinh). 2025 Aug;12(30):e17657. doi: 10.1002/advs.202417657. Epub 2025 Jun 19.
6
Refining Lung Cancer Brain Metastasis Models for Spatiotemporal Dynamic Research and Personalized Therapy.优化用于时空动态研究和个性化治疗的肺癌脑转移模型
Cancers (Basel). 2025 May 7;17(9):1588. doi: 10.3390/cancers17091588.
7
Bio-barrier-adaptable biomimetic nanomedicines combined with ultrasound for enhanced cancer therapy.生物屏障适应性仿生纳米药物联合超声用于增强癌症治疗
Signal Transduct Target Ther. 2025 Apr 25;10(1):137. doi: 10.1038/s41392-025-02217-8.
8
J-type assembled Pt(IV)-coordinated carbon dots for near-infrared light-triggered pyroptosis.用于近红外光触发细胞焦亡的 J 型组装铂（IV）配位碳点
Light Sci Appl. 2025 Apr 15;14(1):163. doi: 10.1038/s41377-025-01834-w.
9
Pharmacokinetics modulation in solid tumors through thrombin-embedded nanomedicine.通过包埋凝血酶的纳米药物实现实体瘤中的药代动力学调控
J Nanobiotechnology. 2025 Apr 4;23(1):268. doi: 10.1186/s12951-025-03302-4.
10
Inorganic Nanomaterials Meet the Immune System: An Intricate Balance.无机纳米材料与免疫系统相遇：一种复杂的平衡。
Adv Healthc Mater. 2025 Apr;14(11):e2404795. doi: 10.1002/adhm.202404795. Epub 2025 Mar 13.
本文引用的文献
1
Histopathological biomarkers for predicting the tumour accumulation of nanomedicines.用于预测纳米药物肿瘤蓄积的组织病理学生物标志物。
Nat Biomed Eng. 2024 Nov;8(11):1366-1378. doi: 10.1038/s41551-024-01197-4. Epub 2024 Apr 8.
2
The exit of nanoparticles from solid tumours.纳米颗粒从实体瘤中的排出。
Nat Mater. 2023 Oct;22(10):1261-1272. doi: 10.1038/s41563-023-01630-0. Epub 2023 Aug 17.
3
Engineering tumoral vascular leakiness with gold nanoparticles.利用金纳米颗粒构建肿瘤血管通透性。
Nat Commun. 2023 Jul 17;14(1):4269. doi: 10.1038/s41467-023-40015-4.
4
Machine-learning-assisted single-vessel analysis of nanoparticle permeability in tumour vasculatures.机器学习辅助的肿瘤脉管系统中纳米颗粒通透性的单血管分析。
Nat Nanotechnol. 2023 Jun;18(6):657-666. doi: 10.1038/s41565-023-01323-4. Epub 2023 Feb 13.
5
Macrophages Actively Transport Nanoparticles in Tumors After Extravasation.巨噬细胞在渗出后于肿瘤中主动转运纳米颗粒。
ACS Nano. 2022 Apr 26;16(4):6080-6092. doi: 10.1021/acsnano.1c11578. Epub 2022 Apr 12.
6
Specific Endothelial Cells Govern Nanoparticle Entry into Solid Tumors.特定的内皮细胞控制着纳米颗粒进入实体瘤。
ACS Nano. 2021 Sep 28;15(9):14080-14094. doi: 10.1021/acsnano.1c04510. Epub 2021 Aug 12.
7
The entry of nanoparticles into solid tumours.纳米颗粒进入实体瘤。
Nat Mater. 2020 May;19(5):566-575. doi: 10.1038/s41563-019-0566-2. Epub 2020 Jan 13.
8
Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.血管破裂增强肿瘤血管的通透性，提高纳米颗粒的递送。
Nat Nanotechnol. 2016 Jun;11(6):533-538. doi: 10.1038/nnano.2015.342. Epub 2016 Feb 15.
Zotero 插件