纳米颗粒向肿瘤的递送：从增强渗透与滞留效应和主动靶向机制到临床影响
Nanoparticle Delivery to Tumours: From EPR and ATR Mechanisms to Clinical Impact.
作者信息
Dasgupta Anshuman, Sofias Alexandros Marios, Kiessling Fabian, Lammers Twan
机构信息
Institute for Experimental Molecular Imaging, Center for Biohybrid Medical Systems, RWTH Aachen University Clinic, Aachen, Germany.
出版信息
Nat Rev Bioeng. 2024 Jun 4;2(9):714-716. doi: 10.1038/s44222-024-00203-3.
Abstract
New insights into active versus passive nanoparticle tumour entry and exit mechanisms are enriching the understanding of tumour-targeted drug delivery. Here, we align the principles of the enhanced permeability and retention (EPR) and active transport and retention (ATR), and outline how their mechanistic features may be employed to improve the performance and clinical impact of cancer nanomedicines.
摘要
关于纳米颗粒主动与被动进入和离开肿瘤机制的新见解正在丰富对肿瘤靶向药物递送的理解。在此，我们将增强渗透与滞留（EPR）和主动转运与滞留（ATR）的原理相结合，并概述如何利用它们的机制特征来提高癌症纳米药物的性能和临床影响。
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本文引用的文献
1
Histopathological biomarkers for predicting the tumour accumulation of nanomedicines.
Nat Biomed Eng. 2024 Nov;8(11):1366-1378. doi: 10.1038/s41551-024-01197-4. Epub 2024 Apr 8.
2
The exit of nanoparticles from solid tumours.
Nat Mater. 2023 Oct;22(10):1261-1272. doi: 10.1038/s41563-023-01630-0. Epub 2023 Aug 17.
3
Engineering tumoral vascular leakiness with gold nanoparticles.
Nat Commun. 2023 Jul 17;14(1):4269. doi: 10.1038/s41467-023-40015-4.
4
Machine-learning-assisted single-vessel analysis of nanoparticle permeability in tumour vasculatures.
Nat Nanotechnol. 2023 Jun;18(6):657-666. doi: 10.1038/s41565-023-01323-4. Epub 2023 Feb 13.
5
Macrophages Actively Transport Nanoparticles in Tumors After Extravasation.
ACS Nano. 2022 Apr 26;16(4):6080-6092. doi: 10.1021/acsnano.1c11578. Epub 2022 Apr 12.
6
Specific Endothelial Cells Govern Nanoparticle Entry into Solid Tumors.
ACS Nano. 2021 Sep 28;15(9):14080-14094. doi: 10.1021/acsnano.1c04510. Epub 2021 Aug 12.
7
The entry of nanoparticles into solid tumours.
Nat Mater. 2020 May;19(5):566-575. doi: 10.1038/s41563-019-0566-2. Epub 2020 Jan 13.
8
Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.
Nat Nanotechnol. 2016 Jun;11(6):533-538. doi: 10.1038/nnano.2015.342. Epub 2016 Feb 15.
9
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
Cancer Res. 1986 Dec;46(12 Pt 1):6387-92.
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