Comprehensive assessment of the effectiveness of nitrates with prolonged action in patients with acute myocardial infarction.

In 64 patients with extensive acute myocardial infarction, the effect of the Sustak-forte preparation (nitroglycerin with prolonged action) on central and peripheral haemodynamics and the size of the periinfarction zone was studied. A diminution of the extent of the periinfarction zone was found on the 3rd day of the disease (according to the results of precordial ECG mapping and enzymologic examinations). Analysis of the findings in 476 patients with AMI, using the method of retrospective randomization, documented a statistically significantly better effect of treatment in patients who were given nitrates than in those not receiving them.