Afonskaia N I, Ostrogorskiĭ Iu M, Karpov Iu A, Ivanishvili L O, Iasinovskiĭ V D
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1983;6(2):49-54.
The effect of intravenous nitroglycerin administration on central hemodynamics criteria (end diastolic pressure in the pulmonary artery and cardiac output) was analysed in a controlled study of 60 patients with acute myocardial infarction. Nitroglycerin-induced changes in the parameters were shown to be related to the hemodynamic state at baseline, with the improvement in left ventricular functional state being significant in the presence of left ventricular insufficiency and the changes minimal in the presence of normal baseline parameters. Thus, nitroglycerin can be used in patients with hemodynamic alterations without a detrimental effect.
在一项针对60例急性心肌梗死患者的对照研究中,分析了静脉注射硝酸甘油对中心血流动力学指标(肺动脉舒张压和心输出量)的影响。结果显示,硝酸甘油引起的参数变化与基线时的血流动力学状态相关,在存在左心室功能不全的情况下,左心室功能状态的改善显著,而在基线参数正常的情况下,变化最小。因此,硝酸甘油可用于血流动力学改变的患者,且不会产生有害影响。