Xia Jingdong, Li Xiudan, Bai Chunying, Han Xuchen
Affiliated Hospital of Chifeng University, Chifeng, The Inner Mongol Autonomous Region, Chifeng, People's Republic of China.
Key Laboratory of Research on Human Genetic Diseases at Universities of Inner Mongolia Autonomous Region, Chifeng, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Oct 3;17:3629-3641. doi: 10.2147/DMSO.S481690. eCollection 2024.
Coenzyme Q has garnered significant attention due to its potential role in enhancing cellular energy production and its antioxidant properties. We delve into the therapeutic potential of coenzyme Q in managing diabetes mellitus and its complications, highlighting its capacity to improve mitochondrial function, reduce inflammation and oxidative stress, and correct lipid profiles. Coenzyme Q has shown promise in ameliorating insulin resistance and alleviating complications such as diabetic peripheral neuropathy, kidney disease, retinopathy, and cardiomyopathy. However, its clinical application is limited by poor bio-availability. This review also provides a comprehensive overview of current therapeutic strategies for diabetes complications involving coenzyme Q, including stimulating endogenous synthesis and utilizing carrier transport systems, offering insights into mechanisms for enhancing coenzyme Q bio-availability. These findings suggest that, with improved delivery methods, coenzyme Q could become a valuable adjunct therapy in the management of diabetes mellitus.
辅酶Q因其在增强细胞能量产生方面的潜在作用及其抗氧化特性而备受关注。我们深入探讨辅酶Q在治疗糖尿病及其并发症方面的潜在作用，强调其改善线粒体功能、减轻炎症和氧化应激以及纠正脂质谱的能力。辅酶Q在改善胰岛素抵抗和缓解糖尿病外周神经病变、肾病、视网膜病变和心肌病等并发症方面已显示出前景。然而，其临床应用受到生物利用度差的限制。本综述还全面概述了目前涉及辅酶Q的糖尿病并发症治疗策略，包括刺激内源性合成和利用载体转运系统，为提高辅酶Q生物利用度的机制提供见解。这些发现表明，随着给药方法的改进，辅酶Q可能成为糖尿病管理中有价值的辅助治疗方法。
