Shetty Saidan, Luo Yuting, Thomas Aruna, Guha Subharup, Lott Donovan
Manipal Academy of Higher Education (MAHE), Manipal-576104, Karnataka, India.
Rehabilitation Science PhD Program, University of Florida, Gainesville, FL, USA.
MethodsX. 2024 Sep 12;13:102957. doi: 10.1016/j.mex.2024.102957. eCollection 2024 Dec.
Myotonic dystrophy Type 1 (DM1) is a neuromuscular disease characterized by multisystemic involvement including a progressive loss of muscle mass and strength. Further investigation on the effect of exercise in adults with DM1 is needed to incorporate impactful recent findings to better understand the utility of exercise as an intervention. This review aims to summarize and appraise the literature on the effects of aerobic and strength training on clinical and physiological variables in adults with DM1. Six online databases (PubMed, Scopus, Web of Science, CINAHL, EMBASE, and CENTRAL) will be searched using appropriate search terms. Two reviewers will independently screen the relevant studies and extract the data from the selected articles. The methodological quality of the studies included will be assessed using the Joanna Briggs Critical Appraisal checklist. A meta-analysis will be performed if appropriate. This systematic review and meta-analysis will summarize, synthesize, and appraise evidence on the effect of aerobic and strength training on clinical and physiological variables in adults with DM1. The findings of this review will help in clinical decision-making and guide future researchers working with this patient population.
1型强直性肌营养不良症（DM1）是一种神经肌肉疾病，其特征是多系统受累，包括肌肉质量和力量的逐渐丧失。需要进一步研究运动对成年DM1患者的影响，以纳入近期有影响力的研究结果，从而更好地理解运动作为一种干预措施的效用。本综述旨在总结和评估关于有氧运动和力量训练对成年DM1患者临床和生理变量影响的文献。将使用适当的检索词在六个在线数据库（PubMed、Scopus、Web of Science、CINAHL、EMBASE和CENTRAL）中进行检索。两名评审员将独立筛选相关研究，并从所选文章中提取数据。将使用乔安娜·布里格斯批判性评价清单评估纳入研究的方法学质量。如果合适，将进行荟萃分析。本系统综述和荟萃分析将总结、综合和评估关于有氧运动和力量训练对成年DM1患者临床和生理变量影响的证据。本综述的结果将有助于临床决策，并指导未来针对该患者群体的研究人员。
