Odii Chisom O, Vance David E, B A T Agbor Fiona, Jenkins Amanda, Lavoie Smith Ellen M
School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
Gynecol Oncol Rep. 2024 Sep 21;55:101509. doi: 10.1016/j.gore.2024.101509. eCollection 2024 Oct.
Ovarian cancer remains a significant public health concern for women despite advancements in cancer management. Despite comprising only 2.5 % of cancers in women, ovarian cancer ranks as the fifth leading cause of cancer-related deaths among women, with patients frequently receiving late diagnoses. Chemotherapy, a primary treatment, frequently causes chemotherapy-induced peripheral neuropathy (CIPN), affecting over 60 % of patients and leading to severe sensory, motor, and autonomic nerve impairments. This often necessitates dosage reduction or discontinuation of treatment, thereby increasing mortality. While CIPN's impact on patients is well-documented, there is a paucity of knowledge of how structural and intermediary social determinants of health factors (SDOH), such as socioeconomic and political context, material circumstances such as living and walking conditions, area deprivation, and food availability, affect CIPN severity. The aim of this article was to explore the association between various SDOH and CIPN severity in ovarian cancer, identifying potential research gaps and future research directions. This article seeks to inform targeted interventions to mitigate CIPN's impact by elucidating these associations.
尽管癌症治疗取得了进展，但卵巢癌仍然是女性重大的公共卫生问题。卵巢癌仅占女性癌症的2.5%，却是女性癌症相关死亡的第五大主要原因，患者常常得到晚期诊断。化疗作为主要治疗方法，经常导致化疗引起的周围神经病变（CIPN），影响超过60%的患者，并导致严重的感觉、运动和自主神经损伤。这往往需要减少剂量或停止治疗，从而增加死亡率。虽然CIPN对患者的影响已有充分记录，但对于健康因素的结构和中间社会决定因素（SDOH），如社会经济和政治背景、生活和行走条件等物质环境、地区贫困和食物供应等如何影响CIPN严重程度，却知之甚少。本文的目的是探讨各种SDOH与卵巢癌CIPN严重程度之间的关联，识别潜在的研究差距和未来的研究方向。本文旨在通过阐明这些关联，为减轻CIPN影响的针对性干预措施提供依据。
