Zhou Xiao, Wang Dong-Yang, Ding Cai-Yan, Liu Hui, Sun Zhi-Qin
Changzhou School of Clinical Medicine, Nanjing Medical University, Changzhou 213000, Jiangsu Province, China.
Department of Nursing, School of Pharmacy, Changzhou University, Changzhou 213000, Jiangsu Province, China.
World J Clin Cases. 2022 May 26;10(15):4843-4855. doi: 10.12998/wjcc.v10.i15.4843.
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and long-lasting side effect caused by various anticancer agents that damage sensory, motor and autonomic nerves. It can cause maladaptive behaviors, including disease severity, anxiety, depression, sleep disorders, falls, and social impairment. These disorders have physical, psychological and social effects on patients and can seriously influence their quality of life.
To investigate the current situation of psychosocial adaptation to the disease and its influencing factor in patients with CIPN.
A convenience sampling method was used to select 233 patients with CIPN in our hospital from February to August 2021. In addition, a cross-sectional survey was conducted using a sociodemographic questionnaire, the Self-Report Psychosocial Adjustment to Illness Scale, and the European Organisation for the Research and Treatment of Cancer Quality of Life CIPN20 (QLQ-CIPN20). Factors influencing psychosocial adaptation in patients with CIPN were analyzed by -test or one-way analysis of variance, correlation analysis, multiple stepwise regression analysis, and structural equation models.
The psychosocial adaptation score of patients with CIPN was 52.51 ± 13.18. Multivariate analysis showed that autonomic nerves, tumor stage, motor nerves, education level, availability of caregivers, semi-retirement status, CIPN grade were independent risk factors for patients with CIPN ( < 0.05). Structural equation models showed that QLQ-CIPN20 mediated the relationship between CIPN grade, tumor stage, and psychosocial adaptation.
Patients with CIPN have poor psychosocial adaptation and are affected by a variety of physiological, psychological, and social factors. Patients' adaptive responses should be assessed, and targeted interventions implemented.
化疗引起的周围神经病变（CIPN）是由多种抗癌药物导致的一种严重且持久的副作用，这些药物会损害感觉神经、运动神经和自主神经。它可引发适应不良行为，包括疾病严重程度、焦虑、抑郁、睡眠障碍、跌倒及社交障碍。这些障碍对患者产生生理、心理和社会影响，并会严重影响其生活质量。
调查CIPN患者对疾病的心理社会适应现状及其影响因素。
采用便利抽样法，选取2021年2月至8月我院233例CIPN患者。此外，使用社会人口学问卷、疾病自我报告心理社会适应量表及欧洲癌症研究与治疗组织生活质量CIPN20量表（QLQ-CIPN20）进行横断面调查。通过t检验或单因素方差分析、相关分析、多元逐步回归分析及结构方程模型分析CIPN患者心理社会适应的影响因素。
CIPN患者心理社会适应得分为52.51±13.18。多因素分析显示，自主神经、肿瘤分期、运动神经、受教育程度、照顾者可及性、半退休状态、CIPN分级是CIPN患者的独立危险因素（P<0.05）。结构方程模型显示，QLQ-CIPN20介导了CIPN分级、肿瘤分期与心理社会适应之间的关系。
CIPN患者心理社会适应较差，且受多种生理、心理和社会因素影响。应评估患者的适应性反应并实施针对性干预。
