School of Nursing, University of Alabama, Birmingham, Alabama, USA.
School of Nursing, University of Alabama, Birmingham, Alabama, USA.
Semin Oncol Nurs. 2024 Oct;40(5):151713. doi: 10.1016/j.soncn.2024.151713. Epub 2024 Aug 14.
Provide an overview of scientific reports and literature related to the role(s) of phytocompounds and nutrients in neuroprotection. Discuss how these properties may inform nutrition- and dietary interventions to mitigate chemotherapy-induced peripheral neuropathy (CIPN), for which there are no effective treatments.
A literature search (2010-2023) was conducted in PubMed and Google Scholar where search terms-diet, nutrition, neuroprotection, neurodegenerative diseases, and social determinants of health-were used to narrow articles. From this search, manuscripts were reviewed to provide an overview of the neuroprotective properties of various phytocompounds and nutrients and their observed effects in neurodegenerative conditions and CIPN. Social determinant of health factors (SDOH) related to economic stability and access to nutritious foods were also reviewed as potential barriers to dietary interventions.
Twenty-eight publications were included in this literature review. Phytocompounds found in green tea (EGCG), turmeric (curcumin), cruciferous vegetables (sulforaphane), as well as certain vitamins, are promising, targeted interventions to mitigate CIPN. SDOH factors such as economic instability and limited access to nutritious foods may act as barriers to dietary interventions and limit their generalizability.
Dietary interventions focused on the use of phytocompounds and vitamins with known antioxidant, anti-inflammatory, and neuroprotective properties, hold promise and may provide patients with natural, non-pharmacological therapeutics for the management and/or prevention of CIPN. However, rigorous clinical trial research is needed to explore these effects in humans.
Nurses support cancer survivors at the point-of-care, particularly during and after neurotoxic chemotherapy treatments. If future research supports dietary interventions to mitigate CIPN, nurses will ultimately be positioned to help translate this knowledge into clinical practice through educating patients on how to infuse nutrient-rich foods into their diets. Further, nurses will need to be conscious of SDOH factors that may impede access to these foods.
概述与植物化合物和营养素在神经保护中的作用相关的科学报告和文献。讨论这些特性如何为减轻化疗引起的周围神经病（CIPN）的营养和饮食干预提供信息，目前尚无有效的治疗方法。
在 PubMed 和 Google Scholar 上进行了文献检索（2010-2023 年），使用了“饮食、营养、神经保护、神经退行性疾病和健康的社会决定因素”等关键词来缩小文章范围。从这次搜索中，审查了手稿，以提供各种植物化合物和营养素的神经保护特性及其在神经退行性疾病和 CIPN 中的观察到的作用的概述。还审查了与经济稳定和获得营养食品有关的健康的社会决定因素（SDOH），因为它们可能是饮食干预的障碍。
本文献综述包括 28 篇出版物。绿茶（EGCG）、姜黄（姜黄素）、十字花科蔬菜（萝卜硫素）中的植物化合物以及某些维生素是有希望的靶向干预措施，可以减轻 CIPN。经济不稳定和获得营养食品的机会有限等 SDOH 因素可能成为饮食干预的障碍，并限制其普遍性。
专注于使用具有已知抗氧化、抗炎和神经保护特性的植物化合物和维生素的饮食干预措施有希望为患者提供用于管理和/或预防 CIPN 的天然、非药物疗法。然而，需要进行严格的临床试验研究来探索这些在人类中的影响。
护士在护理点为癌症幸存者提供支持，特别是在神经毒性化疗治疗期间和之后。如果未来的研究支持饮食干预来减轻 CIPN，那么护士最终将能够通过教育患者如何在饮食中注入富含营养的食物来帮助将这些知识转化为临床实践。此外，护士需要意识到可能阻碍获得这些食物的 SDOH 因素。
