Yang Zijiao, Song Chengfu, Lu Chong
Department of Geriatrics, Yangpu Hospital, School of Medicine Tongji University Shanghai China.
Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University Shanghai China.
Health Sci Rep. 2024 Oct 7;7(10):e70126. doi: 10.1002/hsr2.70126. eCollection 2024 Oct.
Parkinson's disease (PD) and cholelithiasis are a huge public health burden. Although observational studies have suggested a potential link between PD and cholelithiasis, the causal relationship between the two remains uncertain. To address this gap, we performed a two-sample bidirectional Mendelian randomization analysis using genetic tools.
Genome-wide association study summary statistics for all traits were obtained from publicly available databases. We used strict control steps in instrumental variable selection to screen for single nucleotide polymorphisms (SNPs) from summary-level genome-wide association studies. In addition, all -statistics were >10, indicating no weak instrumental bias. The inverse variance weighting (IVW) method was the primary method used to assess causal associations. Four other MR methods (MR-Egger, Weighted Median, Simple mode, and Weighted mode) were also used to complement IVW. Various sensitivity tests were also performed to assess reliability: (1) Cochrane's test for assessing heterogeneity, (2) MR-Egger intercept test and MR-PRESSO global test for assessing horizontal multiplicity, and (3) leave-one-out sensitivity test for determining stability.
We selected a total of 30 SNPs as instrumental variables. It was demonstrated that cholelithiasis had a causal effect on the risk of PD (OR = 1.146, 95% CI: 1.062-1.236, < 0.001) in IVW method.
The results of our analysis revealed an increased risk effect of cholelithiasis against PD, which may give light on new approaches to PD prevention and therapy.
帕金森病（PD）和胆石症是巨大的公共卫生负担。尽管观察性研究表明PD与胆石症之间可能存在联系，但两者之间的因果关系仍不确定。为填补这一空白，我们使用遗传工具进行了两样本双向孟德尔随机化分析。
从公开可用数据库中获取所有性状的全基因组关联研究汇总统计数据。我们在工具变量选择中采用严格的控制步骤，从汇总水平的全基因组关联研究中筛选单核苷酸多态性（SNP）。此外，所有统计量均>10，表明不存在弱工具偏倚。逆方差加权（IVW）方法是用于评估因果关联的主要方法。还使用了其他四种孟德尔随机化方法（MR-Egger、加权中位数、简单模式和加权模式）来补充IVW。还进行了各种敏感性测试以评估可靠性：（1）用于评估异质性的Cochrane检验，（2）用于评估水平多效性的MR-Egger截距检验和MR-PRESSO全局检验，以及（3）用于确定稳定性的留一法敏感性检验。
我们总共选择了30个SNP作为工具变量。在IVW方法中表明，胆石症对PD风险有因果效应（OR = 1.146，95% CI：1.062 - 1.236，P < 0.001）。
我们的分析结果揭示了胆石症对PD的风险增加效应，这可能为PD预防和治疗的新方法提供线索。
