新冠病毒肺炎与健康的中老年人心脏结构和功能重塑有关。
COVID-19 is associated with cardiac structural and functional remodelling in healthy middle-aged and older individuals.
作者信息
Rahman Mushidur, Russell Sophie L, Okwose Nduka C, McGregor Gordon, Maddock Helen, Banerjee Prithwish, Jakovljevic Djordje G
机构信息
Research Centre for Health and Life Sciences, Institute for Health and Wellbeing, Coventry University, Coventry, UK.
Department of Cardiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
出版信息
Clin Physiol Funct Imaging. 2025 Jan;45(1):e12909. doi: 10.1111/cpf.12909. Epub 2024 Oct 8.
BACKGROUND
Coronavirus disease 2019 (COVID-19) was declared a global pandemic in 2019. It remains uncertain to what extent COVID-19 effects the heart in heathy individuals. To evaluate the effect of the COVID-19 on cardiac structure and function in middle-aged and older individuals.
METHODS
A single-centre prospective observational study enroled a total of 124 participants (84 with history of COVID-19 [COVID-19 group] and 40 without a history of COVID-19 [non-COVID group]). All participants underwent echocardiography with speckle tracking to assess cardiac structure and function at rest and during peak exercise.
RESULTS
There were no differences in left and right ventricular diastolic function (p ≥ 0.05) between the COVID-19 and non-COVID-19 groups. Participants in COVID-19 group demonstrated higher left ventricular mass (130 ± 39.8 vs. 113 ± 27.2 g, p = 0.008) and relative wall thickness (0.38 ± 0.07 vs. 0.36 ± 0.13, p = 0.049). Left ventricular global longitudinal strain was reduced in the COVID-19 group at rest and at peak-exercise (rest: 18.3 ± 2.01 vs. 19.3 ± 1.53%, p = 0.004; peak exercise: 19.1 ± 2.20 vs. 21.0 ± 1.58%, p ≤ 0.001). However, no difference was seen in resting left ventricular ejection fraction (58 ± 2.89 vs. 59 ± 2.51%, p = 0.565) between groups. Right ventricular fractional area change was reduced in the COVID-19 group (p = 0.012).
CONCLUSION
Cardiac structural and functional remodelling was observed in middle-aged and older otherwise healthy individuals with a history of COVID-19.
背景
2019年冠状病毒病（COVID-19）被宣布为全球大流行。COVID-19对健康个体心脏的影响程度仍不确定。为了评估COVID-19对中老年人心脏结构和功能的影响。
方法
一项单中心前瞻性观察性研究共纳入124名参与者（84名有COVID-19病史者[COVID-19组]和40名无COVID-19病史者[非COVID组]）。所有参与者均接受了斑点追踪超声心动图检查，以评估静息和运动高峰时的心脏结构和功能。
结果
COVID-19组和非COVID-19组之间左、右心室舒张功能无差异（p≥0.05）。COVID-19组参与者的左心室质量更高（130±39.8 vs. 113±27.2 g，p = 0.008）和相对室壁厚度更高（0.38±0.07 vs. 0.36±0.13，p = 0.049）。COVID-19组静息和运动高峰时左心室整体纵向应变降低（静息时：18.3±2.01 vs. 19.3±1.53%，p = 0.004；运动高峰时：19.1±2.20 vs. 21.0±1.58%，p≤0.001）。然而，两组之间静息左心室射血分数无差异（58±2.89 vs. 59±2.51%，p = 0.565）。COVID-19组右心室面积变化分数降低（p = 0.012）。
结论
在有COVID-19病史的中老年健康个体中观察到心脏结构和功能重塑。
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