Department of Cardiology, ESIC Medical College and Hospital, Faridabad, Haryana, India.
Department of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, India.
Indian Heart J. 2024 Jul-Aug;76(4):297-302. doi: 10.1016/j.ihj.2024.08.002. Epub 2024 Aug 26.
The persistence and outcomes following myocardial injury subsequent to coronavirus disease-2019 (COVID-19) infection has not been properly elucidated. We assessed sub-clinical bi-ventricular dysfunction using speckle tracking echocardiography (STE) in post COVID-19 patients.
A total of 189 subjects following recovery from COVID-19 infection were enrolled. Detailed echocardiography including STE along with clinical, hematological, biochemical and inflammatory parameters were assessed for all. Patients were divided into four groups (asymptomatic, mild, moderate and severe) based on severity of COVID-19 infection. Additionally, 90 healthy individuals were enrolled as controls. All these patients were followed up for one year following enrolment.
Subclinical LV and right ventricle (RV) dysfunction were seen in 58 (30.7 %) and 55 (29.1 %) patients respectively at baseline. Significant difference was observed in mean LVGLS values among the three groups (mild: -21.5 ± 2.8 %; moderate: -17 ± 7.1 %; severe: -12.1 ± 4 %; P < 0.0001). Over a year of follow-up, significant improvement in LVGLS from baseline (-19.1 ± 5.8 %) was observed (-19.9 ± 4.6 %; P < 0.0001). Similarly, RVFWS (-23.5 ± 6.3 % vs -23.8 ± 5.8 %; P = 0.03) had significant improvement from baseline to one year of follow-up. Reduced LVGLS was reported in 12 (6.3 %) subjects while impaired RVFWS was documented in 10 (5.3 %) subjects at one year of follow-up.
Subclinical LV and RV dysfunction were seen in nearly a third of recovered COVID-19 patients. Over a year of follow-up, significant improvement in subclinical LV and RV dysfunction was noted.
新冠肺炎（COVID-19）感染后继发心肌损伤的持续时间和结局尚未得到充分阐明。我们使用斑点追踪超声心动图（STE）评估 COVID-19 后患者的亚临床双心室功能障碍。
共纳入 189 例 COVID-19 感染后康复的患者。对所有患者进行详细的超声心动图检查，包括 STE，以及临床、血液学、生化和炎症参数。根据 COVID-19 感染的严重程度，将患者分为四组（无症状、轻度、中度和重度）。此外，还招募了 90 名健康个体作为对照组。所有这些患者在入组后随访 1 年。
基线时，分别有 58 例（30.7%）和 55 例（29.1%）患者出现亚临床左心室和右心室功能障碍。三组间平均左室 GLAS 值存在显著差异（轻度：-21.5±2.8%；中度：-17±7.1%；重度：-12.1±4%；P<0.0001）。随访 1 年时，左室 GLAS 值从基线显著改善（-19.1±5.8%；-19.9±4.6%；P<0.0001）。同样，右室 FS（-23.5±6.3%vs-23.8±5.8%；P=0.03）从基线到随访 1 年也有显著改善。随访 1 年时，12 例（6.3%）患者左室 GLAS 值降低，10 例（5.3%）患者右室 FS 受损。
近三分之一的 COVID-19 康复患者存在亚临床左、右心室功能障碍。随访 1 年时，亚临床左、右心室功能障碍明显改善。
