Yoshida Kenji, Nakae Hajime, Satoh Kasumi, Suzuki Yuya, Hirasawa Nobufumi, Kameyama Komei, Okuyama Manabu
Department of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine, Akita, Japan.
Ther Apher Dial. 2025 Apr;29(2):285-290. doi: 10.1111/1744-9987.14216. Epub 2024 Oct 8.
Adiponectin (APN) is a multimeric protein with anti-inflammatory properties that is specifically secreted by adipocytes. Continuous plasma exchange with dialysis (cPED) is a blood purification therapy in which plasma exchange is performed using a selective membrane plasma separator while the dialysate flows outside the hollow fibers.
Patients with sepsis were divided into two groups based on the presence or absence of acute kidney injury (AKI) complications: AKI and non-AKI group.
Plasma APN levels significantly increased after cPED in both groups. The creatinine levels in the AKI group before cPED were significantly higher than those in the non- AKI group. The plasma APN levels in the AKI group before cPED were significantly higher than those in the non-AKI group.
cPED increased APN levels in both patients with and without AKI. Therefore, cPED therapy may be a promising intervention for increasing APN levels in patients with sepsis.
脂联素（APN）是一种具有抗炎特性的多聚体蛋白，由脂肪细胞特异性分泌。连续性血浆置换联合透析（cPED）是一种血液净化疗法，其中使用选择性膜血浆分离器进行血浆置换，同时透析液在中空纤维外部流动。
根据是否存在急性肾损伤（AKI）并发症，将脓毒症患者分为两组：AKI组和非AKI组。
两组患者在cPED后血浆APN水平均显著升高。cPED前AKI组的肌酐水平显著高于非AKI组。cPED前AKI组的血浆APN水平显著高于非AKI组。
cPED可使有或无AKI的患者的APN水平升高。因此，cPED疗法可能是提高脓毒症患者APN水平的一种有前景的干预措施。
