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苦木素类化合物作为有前景的抗癌药物。

Quassinoids as Promising Anti-cancer Agents.

作者信息

Mishra Tripti, Banik Bimal Krishna

机构信息

Centre of Innovative and Applied Bioprocessing (CIAB), Sector-81, Knowledge City, Mohali, Punjab, India.

School of Advanced Chemical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, India.

出版信息

Curr Med Chem. 2025;32(26):5433-5473. doi: 10.2174/0109298673313760240911160930.

DOI:10.2174/0109298673313760240911160930
PMID:39377378
Abstract

The use of current anticancer drugs is hampered by significant side effects and high costs. In the pursuit of safer, more effective, and affordable options, researchers have turned to nature as a valuable source of potential anticancer compounds. Quassinoids, a class of natural terpenoids, have garnered attention for their anticancer properties. This comprehensive review aims to shed light on natural quassinoids and their anticancer effects, offering valuable insights for researchers dedicated to the development of novel anticancer therapeutics.

摘要

目前抗癌药物的使用受到严重副作用和高成本的阻碍。为了寻求更安全、更有效且更经济实惠的选择,研究人员将目光投向了大自然,将其视为潜在抗癌化合物的宝贵来源。苦木素类化合物作为一类天然萜类化合物,因其抗癌特性而备受关注。这篇综述旨在阐明天然苦木素类化合物及其抗癌作用,为致力于开发新型抗癌疗法的研究人员提供有价值的见解。

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Skin Res Technol. 2022 Mar;28(2):203-211. doi: 10.1111/srt.13111. Epub 2021 Nov 15.
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A novel P38α MAPK activator Bruceine A exhibits potent anti-pancreatic cancer activity.一种新型P38α丝裂原活化蛋白激酶激活剂鸦胆子素A具有强大的抗胰腺癌活性。
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Bruceine A induces cell growth inhibition and apoptosis through PFKFB4/GSK3β signaling in pancreatic cancer.
布瑞宁 A 通过 PFKFB4/GSK3β 信号通路诱导胰腺癌细胞生长抑制和凋亡。
Pharmacol Res. 2021 Jul;169:105658. doi: 10.1016/j.phrs.2021.105658. Epub 2021 May 14.
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Nrf2/HO-1 Axis Regulates the Angiogenesis of Gastric Cancer via Targeting VEGF.Nrf2/HO-1轴通过靶向血管内皮生长因子调控胃癌血管生成。
Cancer Manag Res. 2021 Apr 12;13:3155-3169. doi: 10.2147/CMAR.S292461. eCollection 2021.
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Cancer statistics for the year 2020: An overview.2020年癌症统计数据概述。
Int J Cancer. 2021 Apr 5. doi: 10.1002/ijc.33588.
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An in vitro study on the reversal of epithelial to mesenchymal transition by brusatol and its synergistic properties in triple-negative breast cancer cells.体外研究白藜芦醇对三阴性乳腺癌细胞上皮间质转化的逆转作用及其协同作用。
J Pharm Pharmacol. 2021 Apr 27;73(6):749-757. doi: 10.1093/jpp/rgab018.
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HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer.HIPK2 是预测 II 期结直肠癌辅助化疗疗效的潜在标志物。
Oncol Rep. 2021 Mar;45(3):899-910. doi: 10.3892/or.2020.7912. Epub 2020 Dec 24.
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Anti-Cancer Effects of Glaucarubinone in the Hepatocellular Carcinoma Cell Line Huh7 via Regulation of the Epithelial-To-Mesenchymal Transition-Associated Transcription Factor Twist1.通过调控上皮间质转化相关转录因子 Twist1 发挥抗肝癌细胞系 Huh7 作用的角鲨烯酮
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