Pôle de Recherche en Physiopathologie de la Reproduction, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.
Healthy Ageing Research Center, Neyshabur University of Medical Sceieces, Neyshabur, Iran.
J Endocrinol. 2024 Nov 18;263(3). doi: 10.1530/JOE-24-0140. Print 2024 Dec 1.
Polycystic ovary syndrome (PCOS) is a primary endocrinological disorder in women of reproductive age that is characterized by androgen excess and ovulatory irregularities. This syndrome is associated with adipose tissue dysfunction, an elevated risk of insulin resistance, hyperinsulinemia, obesity, and type 2 diabetes. Adipocyte dysfunction affects the secretion of adipokines and pro-inflammatory cytokines. Nevertheless, adipose tissue is not an exclusive source of adipokines as it can also be produced locally by reproductive tissues. Although adipokines have been recognized in the development of PCOS, the role of oncostatin M (OSM), a multifaceted adipokine, remains unclear. Current evidence suggests that this cytokine is associated with key aspects of the syndrome, including obesity, insulin resistance, hyperandrogenism, and inflammation. However, the data are often contradictory, likely due to variations in study designs, methodologies, and species differences. By investigating the link between OSM and PCOS-associated issues, this review identified the potential role of this adipokine in PCOS pathogenesis. This underscores the need for further research to clarify its predominant effects and assess its relevance as a therapeutic target.
多囊卵巢综合征（PCOS）是一种育龄妇女的主要内分泌疾病，其特征是雄激素过多和排卵不规则。该综合征与脂肪组织功能障碍、胰岛素抵抗、高胰岛素血症、肥胖和 2 型糖尿病风险升高有关。脂肪细胞功能障碍影响脂肪因子和促炎细胞因子的分泌。然而，脂肪组织并不是脂肪因子的唯一来源，因为它也可以由生殖组织局部产生。尽管脂肪因子在 PCOS 的发展中已得到确认，但多效性脂肪因子——肿瘤坏死因子样弱诱导因子（OSM）的作用仍不清楚。目前的证据表明，这种细胞因子与该综合征的关键方面有关，包括肥胖、胰岛素抵抗、高雄激素血症和炎症。然而，这些数据往往存在矛盾，这可能是由于研究设计、方法和物种差异的变化所致。通过研究 OSM 与 PCOS 相关问题之间的联系，本综述确定了这种脂肪因子在 PCOS 发病机制中的潜在作用。这凸显了进一步研究以阐明其主要作用并评估其作为治疗靶点的相关性的必要性。
