Hourani Tetiana, Sharma Amit, Luwor Rodney B, Achuthan Adrian A
Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Australia.
Department of Integrated Oncology, Center for Integrated Oncology (CIO) Bonn, University Hospital Bonn, Bonn, Germany.
Int Rev Immunol. 2025;44(2):82-97. doi: 10.1080/08830185.2024.2411998. Epub 2024 Oct 8.
TGF-β is a pivotal cytokine that orchestrates various aspects of cancer progression, including tumor growth, metastasis, and immune evasion. In this review, we present a comprehensive overview of the multifaceted role of transforming growth factor β (TGF-β) in cancer biology, focusing on its intricate interactions with monocytes and macrophages within the tumor microenvironment (TME). We specifically discuss how TGF-β modulates monocyte and macrophage activities, leading to immunosuppression and tumor progression. We conclude with the current translational and clinical efforts targeting TGF-β, recognizing the promising role of this strategy in immunooncology.
转化生长因子-β（TGF-β）是一种关键细胞因子，它协调癌症进展的各个方面，包括肿瘤生长、转移和免疫逃逸。在本综述中，我们全面概述了转化生长因子β（TGF-β）在癌症生物学中的多方面作用，重点关注其在肿瘤微环境（TME）中与单核细胞和巨噬细胞的复杂相互作用。我们特别讨论了TGF-β如何调节单核细胞和巨噬细胞的活性，导致免疫抑制和肿瘤进展。我们最后阐述了目前针对TGF-β的转化研究和临床努力，认识到这一策略在免疫肿瘤学中的潜在作用。
