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利用联合反射-失真耳声发射谱检测轻度感觉神经性听力损失。

Detection of mild sensory hearing loss using a joint reflection-distortion otoacoustic emission profile.

机构信息

Caruso Department of Otolaryngology, Keck School of Medicine, University of Southern California, 1640 Marengo Avenue, Suite 326, Los Angeles, California 90033, USA.

出版信息

J Acoust Soc Am. 2024 Oct 1;156(4):2220-2236. doi: 10.1121/10.0030399.

Abstract

Measuring and analyzing both nonlinear-distortion and linear-reflection otoacoustic emissions (OAEs) combined creates what we have termed a "joint-OAE profile." Here, we test whether these two classes of emissions have different sensitivities to hearing loss and whether our joint-OAE profile can detect mild-moderate hearing loss better than conventional OAE protocols have. 2f1-f2 distortion-product OAEs and stimulus-frequency OAEs were evoked with rapidly sweeping tones in 300 normal and impaired ears. Metrics included OAE amplitude for fixed-level stimuli as well as slope and compression features derived from OAE input/output functions. Results show that mild-moderate hearing loss impacts distortion and reflection emissions differently. Clinical decision theory was applied using OAE metrics to classify all ears as either normal-hearing or hearing-impaired. Our best OAE classifiers achieved 90% or better hit rates (with false positive rates of 5%-10%) for mild hearing loss, across a nearly five-octave range. In summary, results suggest that distortion and reflection emissions have distinct sensitivities to hearing loss, which supports the use of a joint-OAE approach for diagnosis. Results also indicate that analyzing both reflection and distortion OAEs together to detect mild hearing loss produces outstanding accuracy across the frequency range, exceeding that achieved by conventional OAE protocols.

摘要

测量和分析非线性失真和线性反射耳声发射(OAE)相结合,形成了我们所谓的“联合 OAE 谱”。在这里,我们测试这两类发射是否对听力损失具有不同的敏感性,以及我们的联合 OAE 谱是否比传统 OAE 方案更能检测轻度至中度听力损失。使用快速扫频音在 300 个正常和受损耳朵中诱发 2f1-f2 失真产物 OAE 和刺激频率 OAE。度量标准包括固定水平刺激的 OAE 幅度以及从 OAE 输入/输出函数中得出的斜率和压缩特征。结果表明,轻度至中度听力损失对失真和反射发射的影响不同。使用 OAE 度量标准应用临床决策理论将所有耳朵分类为正常听力或听力受损。我们最好的 OAE 分类器在近五个倍频程范围内实现了 90%或更高的命中率(假阳性率为 5%-10%),用于轻度听力损失。总之,结果表明失真和反射发射对听力损失具有不同的敏感性,支持使用联合 OAE 方法进行诊断。结果还表明,同时分析反射和失真 OAE 以检测轻度听力损失,在整个频率范围内产生出色的准确性,超过了传统 OAE 方案的准确性。

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本文引用的文献

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Swept Along: Measuring Otoacoustic Emissions Using Continuously Varying Stimuli.被扫过的:使用连续变化的刺激测量耳声发射。
J Assoc Res Otolaryngol. 2024 Apr;25(2):91-102. doi: 10.1007/s10162-024-00934-5. Epub 2024 Feb 26.

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