Independent Researcher, Toronto, Ontario, Canada.
Bioconjug Chem. 2024 Nov 20;35(11):1639-1686. doi: 10.1021/acs.bioconjchem.4c00137. Epub 2024 Oct 8.
Accurate detection, treatment, and imaging of diseases are important for effective treatment outcomes in patients. In this regard, bubbles have gained much attention, due to their versatility. Bubbles usually 1 nm to 10 μm in size can be produced and loaded with a variety of lipids, polymers, proteins, and therapeutic and imaging agents. This review details the different production and loading methods for bubbles, for imaging and treatment of diseases/conditions such as cancer, tumor angiogenesis, thrombosis, and inflammation. Bubbles can also be used for perfusion measurements, important for diagnostic and therapeutic decision making in cardiac disease. The different factors important in the stability of bubbles and the different techniques for characterizing their physical and chemical properties are explained, for developing bubbles with advanced therapeutic and imaging features. Hence, the review provides important insights for researchers studying bubbles for biomedical applications.
准确的疾病检测、治疗和成像对于患者的有效治疗结果至关重要。在这方面，由于其多功能性，气泡受到了广泛关注。通常可以产生大小为 1nm 至 10μm 的气泡，并可以将其装载各种脂质、聚合物、蛋白质以及治疗和成像试剂。本文详细介绍了不同的气泡产生和装载方法，用于成像和治疗癌症、肿瘤血管生成、血栓形成和炎症等疾病/病症。气泡还可用于灌注测量，这对于心脏病的诊断和治疗决策非常重要。本文还解释了影响气泡稳定性的不同因素，以及用于描述其物理和化学性质的不同技术，以开发具有先进治疗和成像功能的气泡。因此，该综述为研究用于生物医学应用的气泡的研究人员提供了重要的见解。
