Department of Biochemistry, Weill Cornell Medicine, Cornell University, 1300 York Ave., New York, NY 10065, USA.
Sci Signal. 2024 Oct 8;17(857):eads1228. doi: 10.1126/scisignal.ads1228.
Developmental axon pruning is controlled by a careful balance of pro- and anti-apoptotic signals, which are activated in response to external cues to sculpt mature neuronal circuitry. In this issue of , Abraham define a safeguard against apoptotic axon pruning and illustrate that Siah3 represses Parkin-mediated mitophagy to control the availability of axonal mitochondria that activate the pruning process.
发育中的轴突修剪受到促凋亡和抗凋亡信号的精细平衡的控制，这些信号会对外界线索做出反应，从而塑造成熟的神经元回路。在本期的《自然》杂志中，Abraham 定义了一种防止凋亡性轴突修剪的保护机制，并表明 Siah3 抑制 Parkin 介导的线粒体自噬，以控制激活修剪过程的轴突线粒体的可用性。
