大鼠舌黏膜癌前和肿瘤性变化的实验诱导
Experimental induction of preneoplastic and neoplastic changes in the lingual mucosa of rats.
作者信息
Steidler N E, Rich A M, Reade P C
出版信息
J Biol Buccale. 1985 Dec;13(4):339-46.
PMID:3937843
Abstract
Squamous cell carcinomas of the tongue can be produced reliably in rats by repeated application of the carcinogen 4-nitroquinoline-1-oxide. The histopathological changes in the lingual epithelium during carcinogenesis were progressive, passing through mild to moderate to severe epithelial atypia before the development of squamous cell carcinoma. Initiation, with its putative irreversible cellular changes, occurred within 4 weeks.
摘要
通过反复应用致癌物4-硝基喹啉-1-氧化物，可在大鼠中可靠地诱发舌鳞状细胞癌。致癌过程中舌上皮的组织病理学变化是渐进性的，在鳞状细胞癌发生之前，经历了轻度、中度到重度上皮异型增生。引发阶段及其假定的不可逆细胞变化在4周内发生。
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