Phifer C B, Prior D J
J Exp Biol. 1985 Sep;118:405-21. doi: 10.1242/jeb.118.1.405.
When terrestrial slugs (Limax maximus) are dehydrated to 65-70% of their initial body weight (IBW) their feeding responsiveness is greatly decreased. There is a 90% decrease in feeding responsiveness when slugs are injected with hyperosmotic mannitol solution that raises the haemolymph osmolality to that of slugs dehydrated to 65-70% IBW (i.e. 200 mosmol kg-1 H2O). The duration of the Feeding Motor Programme (FMP) that can be recorded from an isolated CNS-lip preparation is reduced by increasing the osmolality of the saline bathing the preparation. The osmolality of the saline that can modify the FMP corresponds to that of the haemolymph of a slug dehydrated to 65-70% IBW. The pattern of the motor programme is not affected. A gradual increase in saline osmolality which temporally mimics the progressive increase in haemolymph osmolality of a dehydrating slug also causes a decrease in the duration of the FMP. The neural network underlying the FMP appears to adapt to hyperosmotic saline since the duration of FMP bouts gradually returns to normal levels after long-term exposure (6-8 h).
当陆生蛞蝓（大蛞蝓）脱水至其初始体重（IBW）的65 - 70%时，它们的摄食反应性会大幅下降。当给蛞蝓注射高渗甘露醇溶液使血淋巴渗透压升至脱水至65 - 70% IBW的蛞蝓的渗透压水平（即200 mosmol kg⁻¹ H₂O）时，摄食反应性会降低90%。从分离的中枢神经系统 - 唇部制剂中记录到的摄食运动程序（FMP）的持续时间会因增加浸泡该制剂的盐水的渗透压而缩短。能够改变FMP的盐水渗透压与脱水至65 - 70% IBW的蛞蝓的血淋巴渗透压相对应。运动程序的模式不受影响。盐水渗透压的逐渐增加在时间上模拟了脱水蛞蝓血淋巴渗透压的逐渐升高，这也会导致FMP持续时间的缩短。FMP背后的神经网络似乎能适应高渗盐水，因为在长期暴露（6 - 8小时）后，FMP发作的持续时间会逐渐恢复到正常水平。
