Wang Shuo, Wang Mingjie, Yu Xiaohe, Cao Chuanding, Ding Ying, Lv Mei, Liu Yang, Chu Meiyan, Fang Keren, Liao Zhengchang, Yue Shaojie
Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Pediatr Res. 2025 May;97(6):2074-2081. doi: 10.1038/s41390-024-03621-6. Epub 2024 Oct 9.
This research will explore non-linear relationship between vitamin D status on admission and bronchopulmonary dysplasia (BPD) in preterm infants.
Data were retrospectively collected on preterm infants ≤32 weeks gestation and ≥28 weeks gestation hospitalized in our hospital between Jan. 2019 and Jul. 2022, which were classified into BPD and non-BPD groups according to BPD diagnostic criteria. Independent influences between the two groups were staged using comparison of differences between groups, univariate analysis, multivariate analysis, smoothed curve fitting, and threshold effect staging.
255 preterm infants were enrolled in this research, including 135 males and 120 females, with a mean gestational age of 30.59 ± 0.86 weeks. Vitamin D status on admission was an independent protective factor for BPD in preterm infants, with a 6% reduction in the probability of BPD for every 1 ng/ml increase in vitamin D status on admission (p = 0.036). There was also a non-linear relationship, with each 1 ng/ml increase in vitamin D status on admission being associated with an 87% reduction in the incidence of BPD when vitamin D status was <12.82 ng/ml (p = 0.010).
Vitamin D status on admission and BPD are non-linearly in preterm infants at 28-32 weeks gestation.
Analyzing the relationship between vitamin D status on admission and BPD. A nonlinear relationship and turning point between vitamin D status on admission and BPD was derived by curve fitting and threshold effect. We provide a new reference point for vitamin D supplementation for the prevention of neonatal BPD and to avoid ineffective overmedication.
本研究将探讨早产儿入院时维生素D水平与支气管肺发育不良（BPD）之间的非线性关系。
回顾性收集2019年1月至2022年7月在我院住院的孕周≤32周且≥28周的早产儿数据，根据BPD诊断标准将其分为BPD组和非BPD组。采用组间差异比较、单因素分析、多因素分析、平滑曲线拟合和阈值效应分期等方法分析两组之间的独立影响因素。
本研究共纳入255例早产儿，其中男135例，女120例，平均孕周为30.59±0.86周。入院时维生素D水平是早产儿发生BPD的独立保护因素，入院时维生素D水平每升高1 ng/ml，BPD发生概率降低6%（p = 0.036）。两者之间还存在非线性关系，当维生素D水平<12.82 ng/ml时，入院时维生素D水平每升高1 ng/ml，BPD发生率降低87%（p = 0.010）。
孕28 - 32周早产儿入院时维生素D水平与BPD之间呈非线性关系。
分析入院时维生素D水平与BPD之间的关系。通过曲线拟合和阈值效应得出入院时维生素D水平与BPD之间的非线性关系及转折点。为预防新生儿BPD补充维生素D及避免无效过度用药提供新的参考依据。
