Wang Haibin, Tian Xin, Ji Le, Shi Liang, Wang Ying
Department of Orthopedic Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Department of Rheumatology, Xi'an No. 5 Hospital, Xi'an, Shaanxi, China.
Inflammation. 2024 Oct 9. doi: 10.1007/s10753-024-02151-x.
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which manifests as joint destruction and bone erosion, could be caused by both genetic and environmental factors. Currently, the causes of RA are unknown, and targeted therapies are often associated with side effects and contraindications. The detection rate of RA in women is higher than men (3:1), however, there is still a lack of comprehensive understanding of the relationship between sex and RA. We hypothesized gender differences in RA prevalence and their associated mechanisms by performing genome-wide transcriptome analysis of synovial biopsy samples. The results indicated that myoglobin (MB) was differentially expressed between males and females, with higher expression in males than females in healthy populations, while the opposite was observed in RA patients. MB interacted with HLA class II histocompatibility antigen, DM beta (HLA-DMB) and the inflammatory factor interleukin 6 (IL-6) in the human synovial cell line MH7A.
类风湿性关节炎（RA）是一种慢性炎症性自身免疫性疾病，表现为关节破坏和骨质侵蚀，可能由遗传和环境因素共同引起。目前，RA的病因尚不清楚，靶向治疗通常伴有副作用和禁忌症。女性RA的检出率高于男性（3:1），然而，对于性别与RA之间的关系仍缺乏全面的了解。我们通过对滑膜活检样本进行全基因组转录组分析，推测RA患病率的性别差异及其相关机制。结果表明，肌红蛋白（MB）在男性和女性之间存在差异表达，在健康人群中男性表达高于女性，而在RA患者中则相反。在人滑膜细胞系MH7A中，MB与HLA II类组织相容性抗原DMβ（HLA-DMB）和炎性因子白细胞介素6（IL-6）相互作用。
