Sanquan College of Xinxiang Medical University, Xinxiang, China.
National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
BMC Cancer. 2024 Oct 8;24(1):1238. doi: 10.1186/s12885-024-12992-2.
The study aims to emphasize the clinical importance of the Deep Inspiration Breath Hold (DIBH) technique by quantifying its dosimetric advantages over Free Breathing (FB) in reducing radiation exposure to the heart, liver, and lungs for right-sided breast cancer patients. This evidence supports its potential for routine clinical use to mitigate radiation-induced toxicity.
A systematic retrieval of controlled trials comparing DIBH and FB techniques in postoperative radiotherapy for right-sided breast cancer was conducted utilizing the PubMed, Embase, Cochrane Library, and Web of Science databases. The primary outcomes assessed included the doses of adjacent normal tissues (heart, liver, and lungs). Summary standardized mean differences (SMD) along with 95% confidence intervals (CI) were computed, respectively. StataMP 17 software was selected to perform data analysis.
The study encompassed an analysis of 313 patients derived from seven online studies, comprising 168 individuals in the DIBH group and 269 individuals in the FB group. The findings indicated that the DIBH group received significantly lower irradiation doses to the heart, liver, and lungs in comparison to the FB group, with statistical significance (heart dose: SMD = -0.63, 95% CI -0.85 to -0.41, P < 0.05; liver dose: SMD = -1.15, 95% CI -1.91 to -0.38, P < 0.05; lung dose: SMD = -0.79, 95% CI -1.23 to -0.35, P < 0.05).
This meta-analysis indicated that the application of DIBH during postoperative radiotherapy for right-sided breast cancer markedly decreases radiation exposure to the heart, liver, and lungs, while maintaining consistent tumor dose coverage.
Not applicable.
本研究旨在强调深吸气屏气（DIBH）技术的临床重要性，通过量化其在降低右侧乳腺癌患者心脏、肝脏和肺部辐射暴露方面相对于自由呼吸（FB）的剂量学优势来证明这一点。该证据支持其在常规临床应用中的潜力，以减轻辐射诱导的毒性。
使用 PubMed、Embase、Cochrane 图书馆和 Web of Science 数据库系统检索比较右侧乳腺癌术后放疗中 DIBH 和 FB 技术的对照试验。评估的主要结局包括相邻正常组织（心脏、肝脏和肺部）的剂量。分别计算了汇总标准化均数差（SMD）及 95%置信区间（CI）。选择 StataMP 17 软件进行数据分析。
本研究共纳入 7 项在线研究的 313 例患者，其中 DIBH 组 168 例，FB 组 269 例。结果表明，与 FB 组相比，DIBH 组患者心脏、肝脏和肺部接受的照射剂量显著降低，差异具有统计学意义（心脏剂量：SMD = -0.63，95%CI -0.85 至 -0.41，P<0.05；肝脏剂量：SMD = -1.15，95%CI -1.91 至 -0.38，P<0.05；肺剂量：SMD = -0.79，95%CI -1.23 至 -0.35，P<0.05）。
本荟萃分析表明，在右侧乳腺癌术后放疗中应用 DIBH 可显著降低心脏、肝脏和肺部的辐射暴露，同时保持肿瘤剂量覆盖一致。
不适用。
