全球胆囊癌和胆管癌负担中的性别差异：对2010年至2019年全球疾病负担研究的分析

Sex disparities in global burden of gallbladder and biliary tract cancer: analysis of Global Burden of Disease study from 2010 to 2019.

作者信息

Dutta Priyata, Danpanichkul Pojsakorn, Suparan Kanokphong, Pang Yanfang, Rakwong Krittameth, Fine Michael R, Wijarnpreecha Karn

机构信息

Department of Internal Medicine, Trinity Health Ann Arbor Hospital, Ypsilanti, Michigan, USA.

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

出版信息

J Gastroenterol Hepatol. 2024 Dec;39(12):2863-2871. doi: 10.1111/jgh.16763. Epub 2024 Oct 8.

DOI:10.1111/jgh.16763

PMID:39380148

Abstract

BACKGROUND AND AIM

The global burden of gallbladder and biliary tract cancer (GBTC) has been on the rise, making it a major public health concern. We aim to comprehensively analyze sex disparities in the temporal trends of GBTC incidence, mortality, and disability-adjusted life years (DALYs) regionally and globally from 2010 to 2019.

METHODS

Age-standardized rates of GBTC incidence, death, and DALYs were analyzed utilizing the Global Burden of Disease study 2019.

RESULTS

From 2010 to 2019, the estimated annual percent change (APC) of the age-standardized incidence rates (ASIRs) and age-standardized disability-adjusted life years (ASDALYs) due to GBTC globally decreased in both sexes (males, APC: -0.80%; APC: -1.00%) and (females, APC: -0.89%; APC: -0.96%). At the same time, age-standardized death rates (ASDRs) decreased only in males (APC: -0.82%) and remained stable in females. By regions, ASIRs and ASDR increased in both sexes only in Southeast Asia (SEA) but decreased in the other regions. All regions had decreased ASDALYs except for an increase in ASDALYs for females only in the SEA region (APC: 0.41%), and males have a stable trend.

CONCLUSIONS

Our study reveals substantial geographic variance in the burden of GBTC, specifically in the SEA region. Therefore, localized interventional methodologies must be undertaken to effectively address this global burden from GBTC.

摘要

背景与目的

胆囊癌和胆道癌（GBTC）的全球负担一直在上升，使其成为一个主要的公共卫生问题。我们旨在全面分析2010年至2019年期间全球和各区域GBTC发病率、死亡率及伤残调整生命年（DALY）时间趋势中的性别差异。

方法

利用2019年全球疾病负担研究分析GBTC发病率、死亡率及DALY的年龄标准化率。

结果

2010年至2019年，全球GBTC年龄标准化发病率（ASIR）和年龄标准化伤残调整生命年（ASDALY）的估计年变化百分比（APC）在两性中均下降（男性，APC：-0.80%；APC：-1.00%），（女性，APC：-0.89%；APC：-0.96%）。同时，年龄标准化死亡率（ASDR）仅在男性中下降（APC：-0.82%），在女性中保持稳定。按区域划分，仅在东南亚（SEA）两性的ASIR和ASDR均上升，而在其他区域下降。除SEA区域仅女性的ASDALY上升（APC：0.41%）外，所有区域的ASDALY均下降，男性呈稳定趋势。