预后营养指数与接受卡培他滨治疗的 IV 期结直肠癌患者的全因死亡率相关：越南单中心 24 个月观察性研究。
Prognostic Nutritional Index is Related to All-Cause Mortality in Patients With Stage IV Colorectal Cancer Treated With Capecitabine: Single-Center 24-Month Observational Study in Vietnam.
机构信息
Oncology Center, Bach Mai Hospital, Ha Noi, Vietnam.
Military Hospital 103, Ha Noi, Vietnam.
出版信息
J Clin Lab Anal. 2024 Nov;38(21):e25112. doi: 10.1002/jcla.25112. Epub 2024 Oct 8.
AIM
To determine the mortality rate and the predictive value of the prognostic nutritional index (PNI) for all-cause mortality during the 24 months in patients with stage IV colorectal cancer treated with capecitabine.
METHODS
We conducted a study on 87 stage IV colorectal cancer patients treated with capecitabine. Before the day of treatment, all patients were measured CEA and CRP-hs levels and calculated neutrophil/lympho ratio (NLR) and PNI. Patients were monitored and collected drug side effects and mortality for 24 months.
RESULTS
The mortality rate of study subjects was 60.9%. CRP-hs, NLR, and PNI were independent factors associated with 24-month mortality in patients with stage IV colorectal cancer (p < 0.05 to p < 0.01). At a cut-off value of 38.51, PNI was a predictor for mortality, with the area under the curve (AUC) of 0.88 and p < 0.001.
CONCLUSIONS
PNI was a good predictor of all-cause mortality in patients with stage IV colorectal cancer treated with capecitabine for 24 months.
目的
确定卡培他滨治疗Ⅳ期结直肠癌患者 24 个月全因死亡率和预后营养指数（PNI）的预测价值。
方法
我们对 87 例接受卡培他滨治疗的Ⅳ期结直肠癌患者进行了研究。在治疗前一天，所有患者均测量了 CEA 和 hs-CRP 水平，并计算中性粒细胞/淋巴细胞比值（NLR）和 PNI。对患者进行 24 个月的监测，收集药物不良反应和死亡率数据。
结果
研究对象的死亡率为 60.9%。hs-CRP、NLR 和 PNI 是与Ⅳ期结直肠癌患者 24 个月死亡率相关的独立因素（p<0.05 至 p<0.01）。当 PNI 截断值为 38.51 时，其对死亡率的预测价值最佳，曲线下面积（AUC）为 0.88，p<0.001。
结论
PNI 是卡培他滨治疗 24 个月后Ⅳ期结直肠癌患者全因死亡率的良好预测指标。
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