Li Xin, Chen Tianao, Zheng Zhiyuan, Gao Jie, Wu Yongqi, Wu Xizhi, Jiang Tao, Zhu Zhiqiang, Xu Ronald X
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, 215000, China.
Nano Science and Technology Institute, University of Science and Technology of China, Suzhou, 215123, China.
Small. 2024 Dec;20(51):e2404952. doi: 10.1002/smll.202404952. Epub 2024 Oct 9.
As an open microfluidic technology with excellent anti-fouling and energy-saving properties, liquid gating technology can selectively separate or transfer multiphase fluids, which has shown great application value in the field of biomedical engineering. However, no study has demonstrated that liquid gating technology has the ability to transfer high-viscosity fluids and biologically active substances, and current liquid gating valves are unable to realize smart-responsive pulsed-patterned transfer, which severely limits their application scope. In this paper, liquid gating technology is combined with magnetically responsive materials to prepare a liquid-based magnetic porous membrane (LMPM) with excellent magnetostatic deformation capability and antifouling properties. On this basis, a magnetic liquid gating valve terminal (MLGVT) with patterning transfer capability is developed, and the feasibility of liquid gating technology for transferring high-viscosity fluids and hydrogel bioinks is explored. Meanwhile, a flexible MLGVT is prepared and realized for targeted drug delivery. This study expands the potential of liquid gating technology for drug delivery, cellular transport and smart patches.
作为一种具有优异抗污和节能特性的开放式微流控技术，液体门控技术能够选择性地分离或转移多相流体，在生物医学工程领域展现出了巨大的应用价值。然而，尚无研究表明液体门控技术具备转移高粘度流体和生物活性物质的能力，且目前的液体门控阀无法实现智能响应的脉冲式图案转移，这严重限制了它们的应用范围。在本文中，将液体门控技术与磁响应材料相结合，制备出了具有优异静磁变形能力和抗污性能的液基磁性多孔膜（LMPM）。在此基础上，开发了一种具有图案转移能力的磁性液体门控阀终端（MLGVT），并探索了液体门控技术用于转移高粘度流体和水凝胶生物墨水的可行性。同时，制备并实现了用于靶向给药的柔性MLGVT。本研究拓展了液体门控技术在药物递送、细胞运输和智能贴片方面的潜力。
