Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstr. 20, 01069, Dresden, Germany.
Helmholtz-Zentrum Dresden-Rossendorf e.V, Institute of Ion Beam Physics and Materials Research, Bautzner Landstraße 400, 01328, Dresden, Germany.
Small. 2016 Sep;12(33):4553-62. doi: 10.1002/smll.201601166. Epub 2016 Jul 18.
Information tagging and processing are vital in information-intensive applications, e.g., telecommunication and high-throughput drug screening. Magnetic suspension array technology may offer intrinsic advantages to screening applications by enabling high distinguishability, the ease of code generation, and the feasibility of fast code readout, though the practical applicability of magnetic suspension array technology remains hampered by the lack of quality administration of encoded microcarriers. Here, a logic-controlled microfluidic system enabling controlled synthesis of magnetic suspension arrays in multiphase flow networks is realized. The smart and compact system offers a practical solution for the quality administration and screening of encoded magnetic microcarriers and addresses the universal need of process control for synthesis in microfluidic networks, i.e., on-demand creation of droplet templates for high information capacity. The demonstration of magnetic suspension array technology enabled by magnetic in-flow cytometry opens the avenue toward point-of-care multiplexed bead-based assays, clinical diagnostics, and drug discovery.
信息标记和处理在信息密集型应用中至关重要，例如电信和高通量药物筛选。磁悬浮阵列技术通过实现高可区分性、易于生成代码以及快速代码读取的可行性，可能为筛选应用提供固有优势，尽管编码微载体的质量控制仍然阻碍了磁悬浮阵列技术的实际应用。在这里，实现了一种逻辑控制的微流控系统，该系统能够在多相流网络中控制磁悬浮阵列的合成。这个智能且紧凑的系统为编码磁性微载体的质量控制和筛选提供了实用的解决方案，并满足了微流控网络中合成的过程控制的普遍需求，即按需创建用于高信息量的液滴模板。通过流动磁体中的流式细胞术实现的磁悬浮阵列技术的演示为即时护理多指标基于珠粒的分析、临床诊断和药物发现开辟了道路。
