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Editorial: Immunological non-responders in HIV infection.社论：HIV感染中的免疫无应答者
Front Immunol. 2024 Sep 24;15:1487565. doi: 10.3389/fimmu.2024.1487565. eCollection 2024.
2
HIV immunological non-responders are characterized by extensive immunosenescence and impaired lymphocyte cytokine production capacity.HIV 免疫无应答者的特征是广泛的免疫衰老和受损的淋巴细胞细胞因子产生能力。
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Identification of rare HIV-1-infected patients with extreme CD4+ T cell decline despite ART-mediated viral suppression.鉴定少数尽管接受 ART 介导的病毒抑制但 CD4+ T 细胞仍极度下降的 HIV-1 感染患者。
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Incomplete functional T-cell reconstitution in immunological non-responders at one year after initiation of antiretroviral therapy possibly predisposes them to infectious diseases.在开始抗逆转录病毒治疗一年后，免疫无应答者的功能性 T 细胞重建不完全，可能使他们容易患上传染病。
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5
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6
Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery.HIV 免疫无应答者中的活化树突状细胞和单核细胞：HIV 诱导的干扰素诱导蛋白-10 与未来低 CD4+ 恢复相关。
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8
The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery.NLRP3 炎性小体在 HIV 感染抗逆转录病毒治疗后免疫恢复缺陷的个体中上调。
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Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy. INCAS Study Group.在抗逆转录病毒治疗期间长期抑制HIV-1后，免疫恢复并非总是会发生。INCAS研究小组。
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Genetics and immunological recovery with antiretroviral treatment for HIV.人类免疫缺陷病毒抗逆转录病毒治疗的遗传学与免疫恢复
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引用本文的文献

1
CD4 T cell counts are inversely correlated with anti-gp120 cluster A antibodies in antiretroviral therapy-treated PLWH.在接受抗逆转录病毒治疗的艾滋病毒感染者中，CD4 T细胞计数与抗gp120 A簇抗体呈负相关。
EBioMedicine. 2025 Jul 19;118:105856. doi: 10.1016/j.ebiom.2025.105856.
2
Patterns of immune recovery in people living with HIV who initiated antiretroviral therapy as late presenters.作为晚期就诊者开始接受抗逆转录病毒治疗的HIV感染者的免疫恢复模式。
BMC Infect Dis. 2025 Jul 15;25(1):917. doi: 10.1186/s12879-025-11318-2.
3
Clinical and experimental treatment of residual immune activation in people living with HIV.HIV感染者残留免疫激活的临床与实验性治疗
Clin Exp Immunol. 2025 Jan 21;219(1). doi: 10.1093/cei/uxaf023.

Editorial: Immunological non-responders in HIV infection.

作者信息

Saidakova Evgeniya, Shmagel Konstantin, Sieg Scott, Hunt Peter

机构信息

Biology Department, Perm State University, Perm, Russia.

Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences, Perm, Russia.

出版信息

Front Immunol. 2024 Sep 24;15:1487565. doi: 10.3389/fimmu.2024.1487565. eCollection 2024.

DOI:10.3389/fimmu.2024.1487565
PMID:39381005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11458387/
Abstract
摘要