作为晚期就诊者开始接受抗逆转录病毒治疗的HIV感染者的免疫恢复模式。 - Suppr

Patterns of immune recovery in people living with HIV who initiated antiretroviral therapy as late presenters.

作者信息

Pinto-Cardoso Sandra, Chávez-Torres Monserrat, López-Filloy Mariana, Ávila-Ríos Santiago, Romero-Mora Karla, Peralta-Prado Amy

机构信息

Departamento del Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Colonia Sección XVI, Tlalpan, Ciudad de México, 14080, México.

出版信息

BMC Infect Dis. 2025 Jul 15;25(1):917. doi: 10.1186/s12879-025-11318-2.

DOI:10.1186/s12879-025-11318-2

PMID:40665254

Abstract

摘要

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Patterns of immune recovery in people living with HIV who initiated antiretroviral therapy as late presenters.作为晚期就诊者开始接受抗逆转录病毒治疗的HIV感染者的免疫恢复模式。

BMC Infect Dis. 2025 Jul 15;25(1):917. doi: 10.1186/s12879-025-11318-2.

Intestinal Barrier Impairment and Immune Activation in HIV-Infected Advanced Late Presenters are Not Dependent on CD4 Recovery.HIV 感染晚期出现的肠道屏障损伤和免疫激活与 CD4 恢复无关。

Arch Immunol Ther Exp (Warsz). 2018 Aug;66(4):321-327. doi: 10.1007/s00005-018-0508-8. Epub 2018 Feb 21.

Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+ T-cell recovery upon virologically suppressive combination antiretroviral therapy.肠道连接复合体受损是接受病毒学抑制性联合抗逆转录病毒治疗后CD4+T细胞恢复欠佳的晚期治疗个体的特征。

AIDS. 2016 Apr 24;30(7):991-1003. doi: 10.1097/QAD.0000000000001015.

Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV-infected, treatment-naive adults.无症状、初治的HIV感染成年患者开始抗逆转录病毒治疗的最佳时机。

Cochrane Database Syst Rev. 2010 Mar 17;2010(3):CD008272. doi: 10.1002/14651858.CD008272.pub2.

Altered gut microbiota correlate with different immune responses to HAART in HIV-infected individuals.肠道微生物组的改变与 HIV 感染者对 HAART 的不同免疫反应相关。

BMC Microbiol. 2021 Jan 6;21(1):11. doi: 10.1186/s12866-020-02074-1.

Prevalence and Correlates of Frailty Among Older Adults Living With HIV in the CHANGE HIV Cohort.在 CHANGE HIV 队列中，老年艾滋病毒感染者的虚弱症患病率及其相关因素。

J Acquir Immune Defic Syndr. 2024 Nov 1;97(3):226-231. doi: 10.1097/QAI.0000000000003485. Epub 2024 Oct 7.

Effect of Micronutrients on HIV-Related Clinical Outcomes Among Adults Living With HIV on Antiretroviral Therapy: Systematic Review and Meta-analysis.微量营养素对接受抗逆转录病毒治疗的成人艾滋病毒感染者艾滋病毒相关临床结局的影响：系统评价和荟萃分析

Nutr Rev. 2024 Nov 22. doi: 10.1093/nutrit/nuae171.

Micronutrient supplementation in adults with HIV infection.对感染艾滋病毒的成年人进行微量营养素补充

Cochrane Database Syst Rev. 2017 May 18;5(5):CD003650. doi: 10.1002/14651858.CD003650.pub4.

Aerobic exercise interventions for adults living with HIV/AIDS.针对感染艾滋病毒/艾滋病的成年人的有氧运动干预措施。

Cochrane Database Syst Rev. 2005 Apr 18(2):CD001796. doi: 10.1002/14651858.CD001796.pub2.

Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection.糖尿病相关肠道菌群失调在 HIV 感染者和非感染者中的代谢和炎症紊乱。

Genome Med. 2024 Apr 20;16(1):59. doi: 10.1186/s13073-024-01336-1.

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Mechanisms of HIV-immunologic non-responses and research trends based on gut microbiota.基于肠道微生物群的HIV免疫无反应机制及研究趋势

Front Immunol. 2024 Dec 26;15:1378431. doi: 10.3389/fimmu.2024.1378431. eCollection 2024.

HIV, the gut microbiome and clinical outcomes, a systematic review.人类免疫缺陷病毒、肠道微生物群与临床结局：一项系统评价

PLoS One. 2024 Dec 9;19(12):e0308859. doi: 10.1371/journal.pone.0308859. eCollection 2024.

Alterations of the gut microbiome in HIV infection highlight human anelloviruses as potential predictors of immune recovery.HIV 感染中肠道微生物组的改变突出了人类微小病毒作为免疫恢复潜在预测因子的作用。

Microbiome. 2024 Oct 17;12(1):204. doi: 10.1186/s40168-024-01925-7.

Editorial: Immunological non-responders in HIV infection.社论：HIV感染中的免疫无应答者

Front Immunol. 2024 Sep 24;15:1487565. doi: 10.3389/fimmu.2024.1487565. eCollection 2024.

From dysbiosis to defense: harnessing the gut microbiome in HIV/SIV therapy.从肠道失调到防御：在 HIV/SIV 治疗中利用肠道微生物组。

Microbiome. 2024 Jun 21;12(1):113. doi: 10.1186/s40168-024-01825-w.

Gut microbiome and cardiometabolic comorbidities in people living with HIV.肠道微生物组与 HIV 感染者合并存在的心血管代谢共病。

Microbiome. 2024 Jun 14;12(1):106. doi: 10.1186/s40168-024-01815-y.

The Gut and the Translocated Microbiomes in HIV Infection: Current Concepts and Future Avenues.HIV感染中的肠道与易位微生物群：当前概念与未来方向

Pathog Immun. 2024 May 24;9(1):168-194. doi: 10.20411/pai.v9i1.693. eCollection 2024.

A Two-Faced Gut Microbiome: Butyrogenic and Proinflammatory Bacteria Predominate in the Intestinal Milieu of People Living with HIV from Western Mexico.两面派的肠道微生物组：来自墨西哥西部的 HIV 感染者的肠道环境中以产丁酸菌和促炎菌为主。

Int J Mol Sci. 2024 Apr 29;25(9):4830. doi: 10.3390/ijms25094830.

Factors associated with immunological non-response after ART initiation: a retrospective observational cohort study.抗逆转录病毒治疗起始后免疫无应答相关因素：一项回顾性观察队列研究。

BMC Infect Dis. 2024 Jan 29;24(1):138. doi: 10.1186/s12879-024-09021-9.

Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV.肠道微生物群失调导致的短链脂肪酸产生减少先于 HIV 感染者的发病和死亡。

Cell Rep. 2023 Nov 28;42(11):113336. doi: 10.1016/j.celrep.2023.113336. Epub 2023 Nov 1.

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Patterns of immune recovery in people living with HIV who initiated antiretroviral therapy as late presenters.

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