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骨软骨瘤与软骨肉瘤:诊断难题——病例报告

Osteochondroma versus Chondrosarcoma a Diagnostic Dilemma - a Case Report.

作者信息

Srikanth I Muni, Abraham Vineet Thomas, Joshi Prashant Pranesh, Talwar Pratik

机构信息

Department of Orthopaedics, All India Institute of Medical Sciences, Guntur, Andhra Pradesh, India.

Department of Pathology, All India Institute of Medical Sciences, Guntur, Andhra Pradesh, India.

出版信息

J Orthop Case Rep. 2024 Oct;14(10):10-13. doi: 10.13107/jocr.2024.v14.i10.4792.

Abstract

INTRODUCTION

Osteochondroma is a benign bone tumor, commonly seen as a bony outgrowth from the metaphysis of long bones, having a stalk and cartilage cap. They may be sessile or multiple and usually arise before 20 years of age with no growth beyond puberty. Malignant transformation is a rare complication seen in 1% of solitary cases and 3-5% in the hereditary multiple enchondromatosis variety. Here, we report a rare case of atypical benign osteochondroma with clinical and radiological features suggestive of a malignant transformation.

CASE REPORT

A 17-year-old boy presented to us with a complaint of swelling in his right thigh for 12 years. Radiological features were suggestive of malignant transformation, with bony outgrowth exhibiting heterogeneous calcification, local invasion, and a cartilage cap of size 2.5 cm. Bilateral lung nodules were detected on high-resolution computed tomography. Positron emission tomography scan showed no evidence of metastasis. The patient underwent a wide excision of the tumor and the histopathology revealed it to be a benign osteochondroma. It is an atypical presentation of osteochondroma in which we had a discrepancy in radio-histopathological correlation.

CONCLUSION

In instances of diagnostic uncertainty concerning atypical osteochondroma, opting for an excisional biopsy serves as a prudent next step for the planning of subsequent management. The patient needs to be followed up regularly to look for recurrence or any other signs of metastasis.

摘要

引言

骨软骨瘤是一种良性骨肿瘤,常见于长骨干骺端的骨性赘生物,有蒂和软骨帽。它们可以是无柄的或多发的,通常在20岁之前出现,青春期后不再生长。恶性转化是一种罕见的并发症,在孤立性病例中发生率为1%,在遗传性多发性内生软骨瘤病类型中为3-5%。在此,我们报告一例罕见的非典型良性骨软骨瘤病例,其临床和放射学特征提示恶性转化。

病例报告

一名17岁男孩因右大腿肿胀12年前来就诊。放射学特征提示恶性转化,骨性赘生物表现为不均匀钙化、局部侵犯,软骨帽大小为2.5厘米。高分辨率计算机断层扫描发现双侧肺结节。正电子发射断层扫描显示无转移证据。患者接受了肿瘤广泛切除,组织病理学检查显示为良性骨软骨瘤。这是骨软骨瘤的一种非典型表现,在放射学与组织病理学相关性方面存在差异。

结论

在非典型骨软骨瘤诊断不确定的情况下,选择切除活检是后续治疗计划的谨慎下一步。需要对患者进行定期随访,以观察是否复发或出现任何其他转移迹象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5b4/11458212/6e945e25e5e1/JOCR-14-10-g001.jpg

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