Knockdown of the gene produces altered nervous system structure and impaired muscle endurance phenotypes in .

Calcium signaling plays an integral role in neuronal communication and muscle movement. The junctophilin family of proteins are structural components of calcium channels of the endoplasmic reticulum and are implicated in various neurodegenerative disorders. This study examined the function of , a gene coding for a junctophilin protein in by downregulating gene expression using RNAi through bacterial feeding. Downregulation of altered the physical morphology and impaired thrashing locomotion in wild-type These results are consistent with those of others in demonstrating a role for in muscle physiology.